The effects of dexamphetamine, nabilone (a synthetic cannabinoid agonist), and caffeine on working memory, schizotypy and a tactile illusion in healthy volunteers

Faiz Mohammed Kassim

Research output: ThesisDoctoral Thesis

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Abstract

The thesis aimed to examine the effects of dopamine-releasing agents and cannabinoids on working memory (WM), schizotypy and stimulus binding windows (BWs) by manipulating dopamine and cannabinoid systems implicated in psychosis in healthy participants. The results indicate that, unlike multimodal illusions, alteration of BWs did not occur for this unimodal illusion after administration of dexamphetamine. However, moderate release of dopamine may indirectly influence a unimodal illusion in those that increased in schizotypy. Low activation of the cannabinoid system decreases unimodal illusion, more consistent with antipsychotic than pro-psychotic effects, but deteriorates WM which is a cognitive deficit associated with psychosis.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Rodger, Jennifer, Supervisor
  • Martin-Iverson, Mathew, Supervisor
  • Pixley, Fiona, Supervisor
  • Albrecht, Matt, Supervisor
  • Hood, Sean, Supervisor
Thesis sponsors
Award date1 Jan 2022
DOIs
Publication statusUnpublished - 2021

Embargo information

  • Embargoed from 10/02/2022 to 09/02/2024. Made publicly available on 09/02/2024.

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