The effects of Dexamphetamine and Nabilone on individual perceptual binding windows in healthy volunteers

Mark Lim

doi:10.26182/mm3t-a280

The effects of Dexamphetamine and Nabilone on individual perceptual binding windows in healthy volunteers

Mark Lim

School of Biomedical Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Forms of hallucinations and delusions in schizophrenia are proposed to occur due to alterations inworking memory, via alterations in perceptual binding. These are thought to occur as a consequence of dopaminergic alterations, but some researchers propose a role for cannabis in the aetiology of the disorder. We tested the hypotheses that dexamphetamine, a dopamine-elevating drug, and nabilone, the psychoactive component of cannabis, would increase the capacity of the perceptual binding mechanism as a factor of working memory. Bi-directional and multimodal effects of dexamphetamine and nabilone were found to depend on the individual, and were not associated with WM alterations.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Pixley, Fiona, Supervisor Rodger, Jennifer, Supervisor Martin-Iverson, Mathew, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	2 Oct 2023
DOIs	https://doi.org/10.26182/mm3t-a280
Publication status	Unpublished - 2023

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10.26182/mm3t-a280

THESIS - DOCTOR OF PHILOSOPHY - LIM Jit Hui Mark - 2023
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Cite this

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title = "The effects of Dexamphetamine and Nabilone on individual perceptual binding windows in healthy volunteers",

abstract = "Forms of hallucinations and delusions in schizophrenia are proposed to occur due to alterations inworking memory, via alterations in perceptual binding. These are thought to occur as a consequence of dopaminergic alterations, but some researchers propose a role for cannabis in the aetiology of the disorder. We tested the hypotheses that dexamphetamine, a dopamine-elevating drug, and nabilone, the psychoactive component of cannabis, would increase the capacity of the perceptual binding mechanism as a factor of working memory. Bi-directional and multimodal effects of dexamphetamine and nabilone were found to depend on the individual, and were not associated with WM alterations.",

keywords = "Pharmacology, Schizophrenia, Dexamphetamine, Nabilone, Psychopharmacology, Behavioral Science, Perception, Cognition",

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AB - Forms of hallucinations and delusions in schizophrenia are proposed to occur due to alterations inworking memory, via alterations in perceptual binding. These are thought to occur as a consequence of dopaminergic alterations, but some researchers propose a role for cannabis in the aetiology of the disorder. We tested the hypotheses that dexamphetamine, a dopamine-elevating drug, and nabilone, the psychoactive component of cannabis, would increase the capacity of the perceptual binding mechanism as a factor of working memory. Bi-directional and multimodal effects of dexamphetamine and nabilone were found to depend on the individual, and were not associated with WM alterations.

KW - Pharmacology

KW - Schizophrenia

KW - Dexamphetamine

KW - Nabilone

KW - Psychopharmacology

KW - Behavioral Science

KW - Perception

KW - Cognition

U2 - 10.26182/mm3t-a280

DO - 10.26182/mm3t-a280

M3 - Doctoral Thesis

ER -

The effects of Dexamphetamine and Nabilone on individual perceptual binding windows in healthy volunteers

Abstract

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