The effects of concentration-dependent morphology of self-assembling RADA16 nanoscaffolds on mixed retinal cultures

Dominic Ho, Melinda Fitzgerald, Carole Bartlett, B. Zdyrko, I.A. Luzinov, Sarah Dunlop, Killugudi Swaminathan Iyer

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

RADA16 self-assembling peptide nanofiber scaffolds (SAPNSs) have been shown to have positive effects on neural regeneration following injury to the central nervous system in vivo, but mechanisms are unclear. Here we show that RADA16 SAPNSs form scaffolds of increasing fiber density with increasing peptide concentration which in turn has a concentration-dependent effect on neurons and astrocytes in mixed retinal cultures. Importantly, we report that the final nanoscale fiber architecture is an important factor to consider in designing scaffolds to promote regeneration in the central nervous system.
Original languageEnglish
Pages (from-to)907-910
JournalNanoscale
Volume3
DOIs
Publication statusPublished - 2011

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