The effects of biophysical stimulation on osteogenic differentiation and the mechanisms from ncRNAs

Liwei Mao, Jianmin Guo, Linghui Hu, Lexuan Li, Jiake Xu, Jun Zou

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)

Abstract

Ample proof showed that non-coding RNAs (ncRNAs) play a crucial role in proliferation and differentiation of osteoblasts and bone marrow stromal cells (BMSCs). Varied forms of biophysical stimuli like mechanical strain, fluid shear stress (FSS), microgravity and vibration are verified to regulate ncRNAs expression in osteogenic differentiation and influence the expression of target genes associated with osteogenic differentiation and ultimately regulate bone formation. The consequences of biophysical stimulation on osteogenic differentiation validate the prospect of exercise for the prevention and treatment of osteoporosis. In this review, we tend to summarize the studies on regulation of osteogenic differentiation by ncRNAs beneath biophysical stimulation and facilitate to reveal the regulatory mechanism of biophysical stimulation on ncRNAs, and provide an update for the prevention of bone metabolism diseases by exercise.

Original languageEnglish
Pages (from-to)727-739
Number of pages13
JournalCell Biochemistry and Function
Volume39
Issue number6
Early online date26 May 2021
DOIs
Publication statusPublished - Aug 2021

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