The Effects of Acute High-Intensity Interval Exercise and Hyperinsulinemic-Euglycemic Clamp on Osteoglycin Levels in Young and Middle-Aged Men

Carlie Bauer; Alexander Tacey; Andrew Garnham; Cassandra Smith; Mary N. Woessner; Xuzhu Lin; Navabeh Zarekookandeh; David L. Hare; Joshua R. Lewis; Lewan Parker; Itamar Levinger

doi:10.1002/jbm4.10667

The Effects of Acute High-Intensity Interval Exercise and Hyperinsulinemic-Euglycemic Clamp on Osteoglycin Levels in Young and Middle-Aged Men

Carlie Bauer, Alexander Tacey, Andrew Garnham, Cassandra Smith, Mary N. Woessner, Xuzhu Lin, Navabeh Zarekookandeh, David L. Hare, Joshua R. Lewis, Lewan Parker, Itamar Levinger

UWA Medical School

Research output: Contribution to journal › Article › peer-review

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Abstract

Osteoglycin (OGN) is a leucine-rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high-intensity interval exercise (HIIE) and hyperinsulinemic-euglycemic clamp on circulating levels of OGN as well as whether circulating OGN levels are associated with markers of glycemic control and cardio-metabolic health. Serum was analyzed for OGN (ELISA) levels from 9 middle-aged obese men (58.1 +/- 2.2 years, body mass index [BMI] = 33.1 +/- 1.4 kg.m(-2), mean +/- SEM) and 9 young men (27.8 +/- 1.6 years, BMI = 24.4 +/- 0.08 kg.m(-2)) who previously completed a study involving a euglycemic-hyperinsulinemic clamp at rest and after HIIE (4x4 minutes cycling at approximately 95% peak heart rate (HRpeak), interspersed with 2 minutes of active recovery). Blood pressure, body composition (dual-energy X-ray absorptiometry), and insulin sensitivity (hyperinsulinemic-euglycemic clamp) were assessed. Serum OGN was higher in the young cohort compared with the middle-aged cohort (65.2 +/- 10.1 ng/mL versus 36.5 +/- 4. 5 ng/mL, p

Original language	English
Article number	e10667
Number of pages	6
Journal	JBMR Plus
Volume	6
Issue number	11
DOIs	https://doi.org/10.1002/jbm4.10667
Publication status	Published - Nov 2022

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title = "The Effects of Acute High-Intensity Interval Exercise and Hyperinsulinemic-Euglycemic Clamp on Osteoglycin Levels in Young and Middle-Aged Men",

abstract = "Osteoglycin (OGN) is a leucine-rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high-intensity interval exercise (HIIE) and hyperinsulinemic-euglycemic clamp on circulating levels of OGN as well as whether circulating OGN levels are associated with markers of glycemic control and cardio-metabolic health. Serum was analyzed for OGN (ELISA) levels from 9 middle-aged obese men (58.1 +/- 2.2 years, body mass index [BMI] = 33.1 +/- 1.4 kg.m(-2), mean +/- SEM) and 9 young men (27.8 +/- 1.6 years, BMI = 24.4 +/- 0.08 kg.m(-2)) who previously completed a study involving a euglycemic-hyperinsulinemic clamp at rest and after HIIE (4x4 minutes cycling at approximately 95% peak heart rate (HRpeak), interspersed with 2 minutes of active recovery). Blood pressure, body composition (dual-energy X-ray absorptiometry), and insulin sensitivity (hyperinsulinemic-euglycemic clamp) were assessed. Serum OGN was higher in the young cohort compared with the middle-aged cohort (65.2 +/- 10.1 ng/mL versus 36.5 +/- 4. 5 ng/mL, p",

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author = "Carlie Bauer and Alexander Tacey and Andrew Garnham and Cassandra Smith and Woessner, {Mary N.} and Xuzhu Lin and Navabeh Zarekookandeh and Hare, {David L.} and Lewis, {Joshua R.} and Lewan Parker and Itamar Levinger",

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AU - Tacey, Alexander

AU - Garnham, Andrew

AU - Smith, Cassandra

AU - Woessner, Mary N.

AU - Lin, Xuzhu

AU - Zarekookandeh, Navabeh

AU - Hare, David L.

AU - Lewis, Joshua R.

AU - Parker, Lewan

AU - Levinger, Itamar

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N2 - Osteoglycin (OGN) is a leucine-rich proteoglycan that has been implicated in the regulation of glucose in animal models. However, its relationship with glucose control in humans is unclear. We examined the effect of high-intensity interval exercise (HIIE) and hyperinsulinemic-euglycemic clamp on circulating levels of OGN as well as whether circulating OGN levels are associated with markers of glycemic control and cardio-metabolic health. Serum was analyzed for OGN (ELISA) levels from 9 middle-aged obese men (58.1 +/- 2.2 years, body mass index [BMI] = 33.1 +/- 1.4 kg.m(-2), mean +/- SEM) and 9 young men (27.8 +/- 1.6 years, BMI = 24.4 +/- 0.08 kg.m(-2)) who previously completed a study involving a euglycemic-hyperinsulinemic clamp at rest and after HIIE (4x4 minutes cycling at approximately 95% peak heart rate (HRpeak), interspersed with 2 minutes of active recovery). Blood pressure, body composition (dual-energy X-ray absorptiometry), and insulin sensitivity (hyperinsulinemic-euglycemic clamp) were assessed. Serum OGN was higher in the young cohort compared with the middle-aged cohort (65.2 +/- 10.1 ng/mL versus 36.5 +/- 4. 5 ng/mL, p

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KW - BONE-MUSCLE INTERACTIONS

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KW - HUMAN ASSOCIATION STUDIES

KW - METABOLISM

KW - INSULIN-RESISTANCE

KW - OBESITY

KW - SENSITIVITY

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IS - 11

M1 - e10667

ER -

The Effects of Acute High-Intensity Interval Exercise and Hyperinsulinemic-Euglycemic Clamp on Osteoglycin Levels in Young and Middle-Aged Men

Abstract

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