The effect of tumour antigen properties on the efficiency of cross-presentation

    Research output: ThesisDoctoral Thesis

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    Abstract

    Cross-presentation of tumour antigen is essential for priming tumour-reactive CD8*T cells. However. the effect of tumour antigen characteristics on cross-present at ion efficiency is poorly understood. Such knowledge could facilitate the rational selection of tumour antigens for cancer immunotherapy. This thesis investigated the relationship between the level of tumour antigen in different cellular compartments and cross-presentation efficiency, demonstrating that nuclear antigen is not cross­ presented as efficiently as secreted and cytoplasmic antigens at low concentrations. However, chemotherapy-induced tumour cell death reversed this inefficiency. These findings may have important implications for the design of therapeutic strategies that target nuclear antigens.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date3 Nov 2016
    Publication statusUnpublished - 2016

    Fingerprint

    Cross-Priming
    Neoplasm Antigens
    Nuclear Antigens
    Neoplasms
    Immunotherapy
    Cell Death
    Ions
    T-Lymphocytes
    Antigens
    Drug Therapy

    Cite this

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    title = "The effect of tumour antigen properties on the efficiency of cross-presentation",
    abstract = "Cross-presentation of tumour antigen is essential for priming tumour-reactive CD8*T cells. However. the effect of tumour antigen characteristics on cross-present at ion efficiency is poorly understood. Such knowledge could facilitate the rational selection of tumour antigens for cancer immunotherapy. This thesis investigated the relationship between the level of tumour antigen in different cellular compartments and cross-presentation efficiency, demonstrating that nuclear antigen is not cross­ presented as efficiently as secreted and cytoplasmic antigens at low concentrations. However, chemotherapy-induced tumour cell death reversed this inefficiency. These findings may have important implications for the design of therapeutic strategies that target nuclear antigens.",
    keywords = "Tumour-antigen, Cross-presentation, Chemotherapy",
    author = "Anyaegbu, {Chidozie Christopher}",
    year = "2016",
    language = "English",
    school = "The University of Western Australia",

    }

    Anyaegbu, CC 2016, 'The effect of tumour antigen properties on the efficiency of cross-presentation', Doctor of Philosophy, The University of Western Australia.

    TY - THES

    T1 - The effect of tumour antigen properties on the efficiency of cross-presentation

    AU - Anyaegbu, Chidozie Christopher

    PY - 2016

    Y1 - 2016

    N2 - Cross-presentation of tumour antigen is essential for priming tumour-reactive CD8*T cells. However. the effect of tumour antigen characteristics on cross-present at ion efficiency is poorly understood. Such knowledge could facilitate the rational selection of tumour antigens for cancer immunotherapy. This thesis investigated the relationship between the level of tumour antigen in different cellular compartments and cross-presentation efficiency, demonstrating that nuclear antigen is not cross­ presented as efficiently as secreted and cytoplasmic antigens at low concentrations. However, chemotherapy-induced tumour cell death reversed this inefficiency. These findings may have important implications for the design of therapeutic strategies that target nuclear antigens.

    AB - Cross-presentation of tumour antigen is essential for priming tumour-reactive CD8*T cells. However. the effect of tumour antigen characteristics on cross-present at ion efficiency is poorly understood. Such knowledge could facilitate the rational selection of tumour antigens for cancer immunotherapy. This thesis investigated the relationship between the level of tumour antigen in different cellular compartments and cross-presentation efficiency, demonstrating that nuclear antigen is not cross­ presented as efficiently as secreted and cytoplasmic antigens at low concentrations. However, chemotherapy-induced tumour cell death reversed this inefficiency. These findings may have important implications for the design of therapeutic strategies that target nuclear antigens.

    KW - Tumour-antigen

    KW - Cross-presentation

    KW - Chemotherapy

    M3 - Doctoral Thesis

    ER -