The effect of preoperative aspirin-free interval on red blood cell transfusion requirements in cardiac surgical patients

William M. Weightman, Neville M. Gibbs, Crispin R. Weidmann, Mark A.J. Newman, Diane E. Grey, Matthew R. Sheminant, Wendy N. Erber

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Objective: To compare red blood cell transfusion in first-time coronary artery surgery patients who stopped taking aspirin ≤2 days, 3 to 7 days, or %#62;7 days preoperatively. Design: Observational study. Setting: University-affiliated teaching hospital. Participants: Adult patients (n = 797) undergoing first-time coronary artery surgery on cardiopulmonary bypass who were not receiving other anticoagulant or antiplatelet drugs before surgery. Interventions: None. Measurements and Main Results: Patients were divided into 4 groups based on days since last ingestion of aspirin. Blood products transfused in the groups were (aspirin ≤2 days) (n = 140) 2.2 ± 4 U of red cell concentrate (RCC) (mean ± SD), 1.4 ± 3 U of fresh frozen plasma (FFP), and 2.7 ± 6 U of platelets; (aspirin 3 to 5 days) (n = 255), 1.5 ±2 U of RCC, 0.8 ± 2 U of FFP, and 1.6 ± 4 U of platelets; (aspirin 6 to 7 days) (n = 215), 1.6 ± 3 U of RCC, 0.9 ± 3 U of FFP, and 1.5 ± 3 U of platelets; and (aspirin %#62;7 days) (n = 187), 1.3 ± 2 U of RCC; 0.6 ± 2 U of FFP, and 0.9 ± 2 U of platelets. Conclusion: Patients who stop taking aspirin ≤2 days preoperatively have increased allogenic red blood cell transfusion requirements perioperatively. Patients who stop taking aspirin 3 to 7 days preoperatively have little or no increased requirement for allogenic red blood cell transfusion.

Original languageEnglish
Pages (from-to)54-58
Number of pages5
JournalJournal of Cardiothoracic and Vascular Anesthesia
Volume16
Issue number1
DOIs
Publication statusPublished - 1 Jan 2002
Externally publishedYes

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