The effect of iron status on glyceraldehyde 3-phosphate dehydrogenase expression in rat liver

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Abstract

The influence of iron status on glyceraldehyde 3-phosphate dehydrogenase (GAPDH) gene transcription, mRNA levels and distribution was determined in whole liver samples from adult Wistar rats, While iron loading did not alter GAPDH expression, iron deficiency evoked a 2.3-fold increase in the steady-state level of liver GAPDH mRNA, but did not affect gene transcription or intracellular localisation of the message, Therefore, the overexpression of GAPDH mRNA in iron deficiency is probably due to increased message stability.
Original languageEnglish
Pages (from-to)126-128
JournalFEBS Letters
Volume359
Issue number2-3
DOIs
Publication statusPublished - 1995

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