The Effect of Hypoglycemia on Spectral Moments in EEG Epochs of Different Durations in Type 1 Diabetes Patients

Quoc Cuong Ngo, Rifai Chai, Timothy Jones, Hung Tan Nguyen

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Abstract—The potential of using an electroencephalogram (EEG) to detect hypoglycemia in patients with type 1 diabetes (T1D) has been investigated in both time and frequency domains. Under hyperinsulinemic hypoglycemic clamp conditions, we have shown that the brain’s response to hypoglycemic episodes could be described by the centroid frequency and spectral gyration radius evaluated from spectral moments of EEG signals. The aim of this paper is to investigate the effect of hypoglycemia on spectral moments in EEG epochs of different durations and to propose the optimal time window for hypoglycemia detection without using clamp protocols. The incidence of hypoglycemic episodes at night time in five T1D adolescents was analyzed from selected data of ten days of observations in this study. We found that hypoglycemia is associated with significant changes (P<0.05) in spectral moments of EEG segments in different lengths. Specifically, the changes were more pronounced on the occipital lobe. We used effect size as a measure to determine the best EEG epoch duration for the detection of hypoglycemic episodes. Using Bayesian neural networks, this study showed that 30 second segments provide the best detection rate of hypoglycemia. In addition, Clarke’s error grid analysis confirms the correlation between hypoglycemia and EEG spectral moments of this optimal time window, with 86% of clinically acceptable estimated blood glucose values. These results confirm the potential of using EEG spectral moments to detect the occurrence of hypoglycemia. Index Terms—Electroencephalogram (EEG), hypoglycemia, optimal time window, spectral moment
Original languageEnglish
Article number9337896
Pages (from-to)2857-2865
Number of pages9
JournalIEEE Journal of Biomedical and Health Informatics
Issue number8
Early online date28 Jan 2021
Publication statusPublished - Aug 2021
Externally publishedYes


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