The effect of cytomegalovirus on natural killer cells and T cells in renal transplant recipients

Nandini Bharatkumar Makwana

    Research output: ThesisDoctoral Thesis

    293 Downloads (Pure)

    Abstract

    Cytomegalovirus (CMV) has a worldwide prevalence of 80-100%, and is a common opportunistic infection encountered by renal transplant recipients. CMV becomes latent and may be reactivated without acute symptoms at any lime post-transplant , but its effects on health outcomes are unclear. This thesis demonstrates that CMV has the unique ability to Imprint upon natural killer cell and T cell receptor expression in transplant recipients, with smaller effects in healthy controls. These changes to immune cells could play a role In the development of cardiovascular disease.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date9 Dec 2016
    Publication statusUnpublished - 2016

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