Cytomegalovirus (CMV) has a worldwide prevalence of 80-100%, and is a common opportunistic infection encountered by renal transplant recipients. CMV becomes latent and may be reactivated without acute symptoms at any lime post-transplant , but its effects on health outcomes are unclear. This thesis demonstrates that CMV has the unique ability to Imprint upon natural killer cell and T cell receptor expression in transplant recipients, with smaller effects in healthy controls. These changes to immune cells could play a role In the development of cardiovascular disease.
|Qualification||Doctor of Philosophy|
|Award date||9 Dec 2016|
|Publication status||Unpublished - 2016|