The effect of central retinal venous pressure in patients with central retinal vein occlusion and a high mean area of nonperfusion

© 2014 American Academy of Ophthalmology. ParticipantsEighty-eight patients with CRVO and a high overall mean area (21.6 disc areas) of capillary nonperfusion (CNP) who were followed for 18 months before the availability of intravitreal therapy and who were offered standard care of the time. Purpose To evaluate the effect of central venous pressure (CVP) on visual outcomes and retinal ischemic consequences in patients with central retinal vein occlusion (CRVO). Design Prospective, single-center cohort study. Methods Patients were evaluated at baseline and at 3, 8, and 18 months. At each study visit, measurements of CVP, best-corrected visual acuity (BCVA), area of CNP, retinal fluorescein transit time (FTT), and an evaluation for rubeosis iridis were performed. Main Outcome Measures Evaluation of the effect of different levels of CVP on BCVA, retinal blood flow, and the development of retinal ischemia and rubeosis iridis. Results Mean BCVA was significantly higher in patients with lower CVP at all time points (P