The effect of an angiotensin II, type 1 receptor antagonist on conduit and resistance vessel endothelial function in type 2 diabetes

Craig Cheetham

    Research output: ThesisMaster's Thesis

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    [Truncated] Objectives. This thesis consists of two studies performed to examine the effect on forearm nitric oxide (NO)-dependent vascular endothelial function of an angiotensin II type 1 receptor antagonist, losartan, in subjects with type 2 diabetes. The first study examined the effect of losartan on resistance vessel endothelial function, using strain­ gauge plethysmography and intra-brachial infusions of acetylcholine (ACh), sodium nitroprusside (SNP) and NG-monomethyl-L-arginine (L-NMMA). In the second study, conduit vessel endothelium-dependent and -independent function were assessed via brachial artery diameter response to flow-mediated dilatation (FMD) and sublingual nitroglycerine (GTN) administration, respectively.
    Original languageEnglish
    Awarding Institution
    • The University of Western Australia
    Publication statusUnpublished - 2002


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    This thesis has been made available in the UWA Profiles and Research Repository as part of a UWA Library project to digitise and make available theses completed before 2003. If you are the author of this thesis and would like it removed from the UWA Profiles and Research Repository, please contact

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