[Truncated] Objectives. This thesis consists of two studies performed to examine the effect on forearm nitric oxide (NO)-dependent vascular endothelial function of an angiotensin II type 1 receptor antagonist, losartan, in subjects with type 2 diabetes. The first study examined the effect of losartan on resistance vessel endothelial function, using strain gauge plethysmography and intra-brachial infusions of acetylcholine (ACh), sodium nitroprusside (SNP) and NG-monomethyl-L-arginine (L-NMMA). In the second study, conduit vessel endothelium-dependent and -independent function were assessed via brachial artery diameter response to flow-mediated dilatation (FMD) and sublingual nitroglycerine (GTN) administration, respectively.
|Publication status||Unpublished - 2002|