The effect of a chronic breakdown of the blood-optic nerve barrier on the severed optic nerve in adult rat

Lyn Beazley, M. Tennant, Sarah Dunlop

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The changes brought about in the severed optic nerve of an adult rat when the blood-optic nerve barrier was chronically broken down by the local application of a solution of mannitol is described. Axonal labelling indicated that axons did not regenerate across the lesion site, refuting the suggestion that breakdown of the blood-optic nerve barrier can stimulate axonal regeneration. However, we observed that blood vessels were dilated and, between the eye and lesion site, provided a substrate for regenerating axonal sprouts. We suggest that blood-borne agents may directly or indirectly influence the navigation of the growth cones of regrowing axons.
Original languageEnglish
Pages (from-to)95-101
JournalRestorative Neurology and Neuroscience
Volume10
Publication statusPublished - 1996

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