The early kinetics of cytomegalovirus-specific CD8 T-Cell responses are not affected by antigen load or the absence of perforin or gamma interferon

D.M. Andrews, Chris Andoniou, Peter Fleming, M.J. Smyth, Mariapia Degli-Esposti

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Both innate and adaptive immune responses participate in the control of murine cytomegalovirus (mCMV) infection. In some mouse strains, like BALB/c, the control of infection relies on the activities of CD8+ T cells. mCMV-specific CD8+ T-cell responses are unusual in that, even after mCMV has been controlled in the periphery, the numbers of circulating virus-specific CD8+ T cells remain high compared to those observed in other viral infections. To better understand the generation and maintenance of mCMV-specific CD8+ T-cell responses, we evaluated how antigen load and effector molecules, such as perforin (Prf) and gamma interferon (IFN-{gamma}), influence these responses during acute infection in vivo. Viral burden affected the magnitude, but not the early kinetics, of antigen-specific CD8+ T-cell responses. Similarly, the magnitude of virus-specific CD8+ T-cell expansion was affected by Prf and IFN-{gamma}, but contraction of antigen-specific responses occurred normally in both Prf- and IFN-{gamma}-deficient mice. These data indicate that control of mCMV-specific CD8+ T-cell expansion and contraction is more complex than anticipated and, despite the role of Prf or IFN-{gamma} in controlling viral replication, a full program of T-cell expansion and contraction can occur in their absence.
Original languageEnglish
Pages (from-to)4931-4937
JournalJournal of Virology
Volume82
Issue number10
DOIs
Publication statusPublished - 2008

Fingerprint Dive into the research topics of 'The early kinetics of cytomegalovirus-specific CD8 T-Cell responses are not affected by antigen load or the absence of perforin or gamma interferon'. Together they form a unique fingerprint.

  • Cite this