The diagnostic potential and biological significance of MicroRNA in Malignant Pleural Mesothelioma

Kimberly Birnie

    Research output: ThesisDoctoral Thesis

    130 Downloads (Pure)

    Abstract

    Malignant pleural mesothelioma is a fatal cancer caused by inhalation of asbestos fibres. It is difficult to diagnose and unresponsive to treatment. Modulation of the powerful gene regulators, microRNA, are being utilised to treat diseases. This thesis examined the hypothesis that microRNAs are diagnostic markers and biological targets in mesothelioma. The data shows that 1. particular microRNAs are expressed in pleural effusion cells which are diagnostic for mesothelioma and 2.down­ regulation of miR-223 leads to over-expression of the structural protein Stathmin-1 in mesothelioma, and repressing Stathmin-1 by overexpressing miR-223 is a potential novel therapeutic strategy for this terrible disease.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Supervisors/Advisors
    • Prele, Cecilia, Supervisor
    • Mutsaers, Steve, Supervisor
    • Badrian, Bahareh, Supervisor
    • Thompson, Philip, Supervisor
    Award date5 Jul 2017
    DOIs
    Publication statusUnpublished - 2016

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