Malignant pleural mesothelioma is a fatal cancer caused by inhalation of asbestos fibres. It is difficult to diagnose and unresponsive to treatment. Modulation of the powerful gene regulators, microRNA, are being utilised to treat diseases. This thesis examined the hypothesis that microRNAs are diagnostic markers and biological targets in mesothelioma. The data shows that 1. particular microRNAs are expressed in pleural effusion cells which are diagnostic for mesothelioma and 2.down regulation of miR-223 leads to over-expression of the structural protein Stathmin-1 in mesothelioma, and repressing Stathmin-1 by overexpressing miR-223 is a potential novel therapeutic strategy for this terrible disease.
|Qualification||Doctor of Philosophy|
|Award date||5 Jul 2017|
|Publication status||Unpublished - 2016|