This thesis articulates research for the development of transition metal mediated reactions. The use of high-throughput robotic screening technologies is included which was applied to a directing group guided C-H alkynylation reaction, and a nickel catalysed carbon-sulphur cross-coupling reaction. This optimisation led to the discovery of the first reported case of a nickel catalysed thioetherification of electron rich aryl chlorides with thiols. Synthetic methodologies utilising metal carbenes accessed from alpha-diazocarbonyl precursors and N-sulphonyl-1,2,3-triazoles were also explored. These include a synthetic approach to the caged cyclopropyl ring system of rauvomine B, as well as a modern synthesis of 3,4-dihydro-2H-1,4-oxazines.
|Qualification||Doctor of Philosophy|
|Award date||15 Jun 2020|
|Publication status||Unpublished - 2020|