The Development of Transition Metal Catalysed Methodologies for Efficient Chemical Synthesis

Kieran Jones

Research output: ThesisDoctoral Thesis

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Abstract

This thesis articulates research for the development of transition metal mediated reactions. The use of high-throughput robotic screening technologies is included which was applied to a directing group guided C-H alkynylation  reaction, and a nickel catalysed carbon-sulphur cross-coupling reaction. This optimisation led to the discovery of the first reported case of a nickel catalysed thioetherification of electron rich aryl chlorides with thiols. Synthetic methodologies utilising metal carbenes accessed from alpha-diazocarbonyl precursors and N-sulphonyl-1,2,3-triazoles were also explored. These include a synthetic approach to the caged cyclopropyl ring system of rauvomine B, as well as a modern synthesis of 3,4-dihydro-2H-1,4-oxazines.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Stewart, Scott, Supervisor
  • Piggott, Matthew, Supervisor
  • Gericke, Kersten M., Supervisor, External person
Thesis sponsors
Award date15 Jun 2020
DOIs
Publication statusUnpublished - 2020

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