Abstract
The mechanical properties of cells regulate cell behaviour in both normal and diseased states. However, whilst it is established that accurate measurement of cellular mechanical properties should be performed in three-dimensional (3-D) environments, most characterization techniques in mechanobiology are limited to two dimensions. The aim of this thesis is to develop optical coherence elastography (OCE) towards applications in mechanobiology and we show the first volumetric images of cellular elasticity in 3-D using OCE. This thesis demonstrates OCE has the potential to bridge the gap between the research developed in substrates to how mechanical properties influence cell behaviour in vivo.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 3 Feb 2022 |
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Publication status | Unpublished - 2021 |