A number of biomarkers, used to monitor health and detect blood doping, are measured as a concentration in blood plasma and are thus influenced by plasma volume (PV) fluctuations. Currently, there is no simple method to correct for PV shifts. Here, a novel blood test, capable of estimating absolute PV, is developed from a panel of volume descriptive biomarkers and describes -68% of PV variance. By applying the novel blood test to current anti-doping models, the influence of PV shifts on volumetric anti-doping markers is reduced, improving test sensitivity. Additional applications involve improved patient monitoring and volume management within hospitals.
|Qualification||Doctor of Philosophy|
|Award date||5 Apr 2018|
|Publication status||Unpublished - 2018|