The development of a new model to measure plasma-, red cell- and blood volume and Its applications in refining the Athlete Biological Passport and improving volume management in hospitals

Louisa Margit Lobigs

Research output: ThesisDoctoral Thesis

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Abstract

A number of biomarkers, used to monitor health and detect blood doping, are measured as a concentration in blood plasma and are thus influenced by plasma volume (PV) fluctuations. Currently, there is no simple method to correct for PV shifts. Here, a novel blood test, capable of estimating absolute PV, is developed from a panel of volume descriptive biomarkers and describes -68% of PV variance. By applying the novel blood test to current anti-doping models, the influence of PV shifts on volumetric anti-doping markers is reduced, improving test sensitivity. Additional applications involve improved patient monitoring and volume management within hospitals.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Peeling, Peter, Supervisor
  • Schumacher, Yorck Olaf, Supervisor, External person
  • Dawson, Brian, Supervisor
Thesis sponsors
Award date5 Apr 2018
DOIs
Publication statusUnpublished - 2018

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