TY - BOOK
T1 - The development of a new model to measure plasma-, red cell- and blood volume and Its applications in refining the Athlete Biological Passport and improving volume management in hospitals
AU - Lobigs, Louisa Margit
PY - 2018
Y1 - 2018
N2 - A number of biomarkers, used to monitor health and detect blood doping, are measured as a concentration in blood plasma and are thus influenced by plasma volume (PV) fluctuations. Currently, there is no simple method to correct for PV shifts. Here, a novel blood test, capable of estimating absolute PV, is developed from a panel of volume descriptive biomarkers and describes -68% of PV variance. By applying the novel blood test to current anti-doping models, the influence of PV shifts on volumetric anti-doping markers is reduced, improving test sensitivity. Additional applications involve improved patient monitoring and volume management within hospitals.
AB - A number of biomarkers, used to monitor health and detect blood doping, are measured as a concentration in blood plasma and are thus influenced by plasma volume (PV) fluctuations. Currently, there is no simple method to correct for PV shifts. Here, a novel blood test, capable of estimating absolute PV, is developed from a panel of volume descriptive biomarkers and describes -68% of PV variance. By applying the novel blood test to current anti-doping models, the influence of PV shifts on volumetric anti-doping markers is reduced, improving test sensitivity. Additional applications involve improved patient monitoring and volume management within hospitals.
KW - biological variation
KW - Bayesian inference
KW - plasma volume
KW - intravascular volumes
KW - anti-doping
KW - athlete biological passport
KW - blood doping
KW - haemoglobin concentration
U2 - 10.4225/23/5afb87ea4287c
DO - 10.4225/23/5afb87ea4287c
M3 - Doctoral Thesis
ER -