The development and application of clinically based assays for the detection of cartilage turnover

Sherine Swee Lin Chan

doi:10.26182/5d47a038f2424

The development and application of clinically based assays for the detection of cartilage turnover

Sherine Swee Lin Chan

Research output: Thesis › Doctoral Thesis

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Abstract

[Truncated] Arthritis is characterised by progressive damage of the articular cartilage. More sensitive methods than traditional radiological measures and clinical indices of disease are needed. Biochemical markers of cartilage turnover have been proposed. Few biochemical assays have been validated for reproducibility and sensitivity. Differences between large disease populations need to be determined. Enzyme-linked immunosorbent assays (ELISAs) utilising monoclonal antibodies (MAb) specific for epitopes of a major component of cartilage, aggrecan, have been developed and addressed these criteria. Differences in aggrecan cleavage by aggrecanases and matrix metalloproteinases (MMPs) within disease groups and within different areas within cartilage from patients with osteoarthritis (OA) have also been analysed.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
DOIs	https://doi.org/10.26182/5d47a038f2424
Publication status	Unpublished - 2002

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Chan_Sherine_Swee_Lin_2002
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Cite this

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AB - [Truncated] Arthritis is characterised by progressive damage of the articular cartilage. More sensitive methods than traditional radiological measures and clinical indices of disease are needed. Biochemical markers of cartilage turnover have been proposed. Few biochemical assays have been validated for reproducibility and sensitivity. Differences between large disease populations need to be determined. Enzyme-linked immunosorbent assays (ELISAs) utilising monoclonal antibodies (MAb) specific for epitopes of a major component of cartilage, aggrecan, have been developed and addressed these criteria. Differences in aggrecan cleavage by aggrecanases and matrix metalloproteinases (MMPs) within disease groups and within different areas within cartilage from patients with osteoarthritis (OA) have also been analysed.

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M3 - Doctoral Thesis

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The development and application of clinically based assays for the detection of cartilage turnover

Abstract

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