Projects per year
Abstract
© 2016 The Author(s).Nuclear proteins are often given a concise title that captures their function, such as 'transcription factor,' 'polymerase' or 'nuclear-receptor.' However, for members of the Drosophila behavior/human splicing (DBHS) protein family, no such clean-cut title exists. DBHS proteins are frequently identified engaging in almost every step of gene regulation, including but not limited to, transcriptional regulation, RNA processing and transport, and DNA repair. Herein, we present a coherent picture of DBHS proteins, integrating recent structural insights on dimerization, nucleic acid binding modalities and oligomerization propensity with biological function. The emerging paradigm describes a family of dynamic proteins mediating a wide range of protein-protein and protein-nucleic acid interactions, on the whole acting as a multipurpose molecular scaffold. Overall, significant steps toward appreciating the role of DBHS proteins have been made, but we are only beginning to understand the complexity and broader importance of this family in cellular biology.
Original language | English |
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Pages (from-to) | 3989-4004 |
Journal | Nucleic Acids Research |
Volume | 44 |
Issue number | 9 |
DOIs | |
Publication status | Published - 19 May 2016 |
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Dive into the research topics of 'The DBHS proteins SFPQ, NONO and PSPC1: A multipurpose molecular scaffold'. Together they form a unique fingerprint.Projects
- 3 Finished
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DBHS Protein-protein interactions in gene regulation
National Health & Medical Research Council NHMRC
1/01/13 → 31/08/16
Project: Research
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Dissecting long noncoding RNA-protein complexes
National Health & Medical Research Council NHMRC
1/01/13 → 31/12/15
Project: Research