TY - JOUR
T1 - The Dachshund gene in development and hormone-responsive tumorigenesis
AU - Popov, Vladimir M.
AU - Wu, Kongming
AU - Zhou, Jie
AU - Powell, Michael J.
AU - Mardon, Graeme
AU - Wang, Chenguang
AU - Pestell, Richard G.
N1 - Funding Information:
We thank Atenssa L. Cheek for assistance in preparing this manuscript. Support for this work was provided by R01CA70896, R01CA75503, R01CA86072, R01CA86071 (R.G.P.) and the Susan Komen Breast Cancer Foundation (BCTR0504227; C.W.). The Kimmel Cancer Center was supported by the NIH Cancer Center Core grant P30CA56036 (R.G.P.). This project is funded in part from the Dr. Ralph and Marian C. Falk Medical Research Trust (R.G.P.), grants from Pennsylvania Department of Health (R.G.P. and C.W.), and the Margaret Q. Landenberger Research Foundation (K.W.). The Department specifically disclaims responsibility for any analysis, interpretations or conclusions presented in this paper.
PY - 2010/1
Y1 - 2010/1
N2 - The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb, brain, and gonadal development. In the Drosophila eye, dac is a key component of the Retinal Determination Gene Network (RDGN) governing the normal initiation of the morphogenetic furrow and thereby eye development. Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate and ovarian cancer. The molecular mechanisms by which DACH1 regulates differentiation and tumorigenesis are discussed herein.
AB - The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb, brain, and gonadal development. In the Drosophila eye, dac is a key component of the Retinal Determination Gene Network (RDGN) governing the normal initiation of the morphogenetic furrow and thereby eye development. Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate and ovarian cancer. The molecular mechanisms by which DACH1 regulates differentiation and tumorigenesis are discussed herein.
UR - http://www.scopus.com/inward/record.url?scp=73249123585&partnerID=8YFLogxK
U2 - 10.1016/j.tem.2009.08.002
DO - 10.1016/j.tem.2009.08.002
M3 - Review article
C2 - 19896866
AN - SCOPUS:73249123585
SN - 1043-2760
VL - 21
SP - 41
EP - 49
JO - Trends in Endocrinology and Metabolism
JF - Trends in Endocrinology and Metabolism
IS - 1
ER -
