The Dachshund gene in development and hormone-responsive tumorigenesis

Vladimir M. Popov, Kongming Wu, Jie Zhou, Michael J. Powell, Graeme Mardon, Chenguang Wang, Richard G. Pestell

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length. Functioning as a dominant suppressor of the ellipse mutation, a hypermorphic allele of the Epidermal Growth Factor Receptor (EGFR), the dac gene plays a key role in metazoan development, regulating ocular, limb, brain, and gonadal development. In the Drosophila eye, dac is a key component of the Retinal Determination Gene Network (RDGN) governing the normal initiation of the morphogenetic furrow and thereby eye development. Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate and ovarian cancer. The molecular mechanisms by which DACH1 regulates differentiation and tumorigenesis are discussed herein.

Original languageEnglish
Pages (from-to)41-49
Number of pages9
JournalTrends in Endocrinology and Metabolism
Volume21
Issue number1
DOIs
Publication statusPublished - Jan 2010
Externally publishedYes

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