The cumulative success of ovulation induction therapy with gonadotrophins in therapy-naïve anovulatory women: An observational study

Jennifer Pontré, Fiona Langdon, Kevin Murray, Janet Livingston, Roger Hart

Research output: Contribution to journalArticle

Abstract

Background: The use of gonadotrophins as a first-line treatment for anovulatory infertility has been limited by a perception of a risk of multi-fetal gestation and ovarian hyperstimulation syndrome (OHSS). However, it has recently been recognised as an acceptable first-line treatment if appropriate monitoring is performed. Aims: To determine the cumulative live birth rate, incidence of multiple gestation, cycle cancellation rate and incidence of OHSS for therapy-naïve anovulatory women undergoing ovulation induction with gonadotrophins. Materials and Methods: A prospective observational study of 258 patients undergoing ovulation induction with a ‘low-dose step-up’ protocol was performed over a three-year period across two fertility centres (40% of patients were currently or recently prescribed metformin). Results: Twenty-six percent of patients required concurrent use of luteinising hormone. The cumulative pregnancy and live birth rates were 22.5% and 18.2%, 40.3% and 34.5%, 47.7% and 41.1% after completion of the first, second and third cycles of stimulation, respectively, with a median duration of stimulation of 15 days. No patients developed OHSS and 10.5% of cycles were cancelled due to an excessive or no follicular response. The multiple pregnancy rate was 2%. The cumulative pregnancy rate was reduced for women over 35 years of age (23.8 vs 55.3%, P = 0.006) and for women with a body mass index greater than 25 kg/m2 (40.6 vs 56.7%, P = 0.027). Conclusions: This study demonstrated that ovulation induction with gonadotrophin therapy, in the context of appropriate monitoring, is a safe and effective treatment for young therapy-naïve patients with anovulatory infertility.

Original languageEnglish
Pages (from-to)271-277
Number of pages7
JournalAustralian and New Zealand Journal of Obstetrics and Gynaecology
Volume60
Issue number2
DOIs
Publication statusPublished - Apr 2020

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