The correlation between central and peripheral oxytocin concentrations: a systematic review and meta-analysis

Mathias Valstad, Gail A Alvares, Maiken Egknud, Anna Maria Matziorinis, Ole A. Andreassen, Lars T. Westlye, Daniel S. Quintana

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

There is growing interest in the role of the oxytocin system in social cognition and behavior. Peripheral oxytocin concentrations are regularly used to approximate central concentrations in psychiatric research, however, the validity of this approach is unclear. Here we conducted a pre-registered systematic search and meta-analysis of correlations between central and peripheral oxytocin concentrations. A search of databases yielded 17 eligible studies, resulting in a total sample size of 516 participants and subjects. Overall, a positive association between central and peripheral oxytocin concentrations was revealed [r=0.29, 95% CI (0.14, 0.42), p

Original languageEnglish
Pages (from-to)117-124
JournalNeuroscience & Biobehavioral Reviews
Volume78
DOIs
Publication statusPublished - Jul 2017

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