The contribution of geogenic particulate matter to lung disease in indigenous children

Carrington C.J. Shepherd, Holly D. Clifford, Francis Mitrou, Shannon M. Melody, Ellen J. Bennett, Fay H. Johnston, Luke D. Knibbs, Gavin Pereira, Janessa L. Pickering, Teck H. Teo, Lea Ann S. Kirkham, Ruth B. Thornton, Anthony Kicic, Kak Ming Ling, Zachary Alach, Matthew Lester, Peter Franklin, David Reid, Graeme R. Zosky

Research output: Contribution to journalArticle

Abstract

Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02–3.06]) and lower (OR 1.99 95% CI [1.08–3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20–7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high.

Original languageEnglish
Article number2636
Number of pages12
JournalInternational Journal of Environmental Research and Public Health
Volume16
Issue number15
DOIs
Publication statusPublished - 1 Aug 2019

Fingerprint

Particulate Matter
Lung Diseases
Dust
Ear Diseases
Western Australia
Haemophilus influenzae
Health Status
Hospitalization
Epithelial Cells
Respiratory Tract Diseases
Health
Vulnerable Populations
Interleukin-8
Respiratory Tract Infections
Caregivers
Logistic Models
Population

Cite this

Shepherd, Carrington C.J. ; Clifford, Holly D. ; Mitrou, Francis ; Melody, Shannon M. ; Bennett, Ellen J. ; Johnston, Fay H. ; Knibbs, Luke D. ; Pereira, Gavin ; Pickering, Janessa L. ; Teo, Teck H. ; Kirkham, Lea Ann S. ; Thornton, Ruth B. ; Kicic, Anthony ; Ling, Kak Ming ; Alach, Zachary ; Lester, Matthew ; Franklin, Peter ; Reid, David ; Zosky, Graeme R. / The contribution of geogenic particulate matter to lung disease in indigenous children. In: International Journal of Environmental Research and Public Health. 2019 ; Vol. 16, No. 15.
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The contribution of geogenic particulate matter to lung disease in indigenous children. / Shepherd, Carrington C.J.; Clifford, Holly D.; Mitrou, Francis; Melody, Shannon M.; Bennett, Ellen J.; Johnston, Fay H.; Knibbs, Luke D.; Pereira, Gavin; Pickering, Janessa L.; Teo, Teck H.; Kirkham, Lea Ann S.; Thornton, Ruth B.; Kicic, Anthony; Ling, Kak Ming; Alach, Zachary; Lester, Matthew; Franklin, Peter; Reid, David; Zosky, Graeme R.

In: International Journal of Environmental Research and Public Health, Vol. 16, No. 15, 2636, 01.08.2019.

Research output: Contribution to journalArticle

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AU - Shepherd, Carrington C.J.

AU - Clifford, Holly D.

AU - Mitrou, Francis

AU - Melody, Shannon M.

AU - Bennett, Ellen J.

AU - Johnston, Fay H.

AU - Knibbs, Luke D.

AU - Pereira, Gavin

AU - Pickering, Janessa L.

AU - Teo, Teck H.

AU - Kirkham, Lea Ann S.

AU - Thornton, Ruth B.

AU - Kicic, Anthony

AU - Ling, Kak Ming

AU - Alach, Zachary

AU - Lester, Matthew

AU - Franklin, Peter

AU - Reid, David

AU - Zosky, Graeme R.

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N2 - Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02–3.06]) and lower (OR 1.99 95% CI [1.08–3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20–7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high.

AB - Indigenous children have much higher rates of ear and lung disease than non-Indigenous children, which may be related to exposure to high levels of geogenic (earth-derived) particulate matter (PM). The aim of this study was to assess the relationship between dust levels and health in Indigenous children in Western Australia (W.A.). Data were from a population-based sample of 1077 Indigenous children living in 66 remote communities of W.A. (>2,000,000 km2), with information on health outcomes derived from carer reports and hospitalisation records. Associations between dust levels and health outcomes were assessed by multivariate logistic regression in a multi-level framework. We assessed the effect of exposure to community sampled PM on epithelial cell (NuLi-1) responses to non-typeable Haemophilus influenzae (NTHi) in vitro. High dust levels were associated with increased odds of hospitalisation for upper (OR 1.77 95% CI [1.02–3.06]) and lower (OR 1.99 95% CI [1.08–3.68]) respiratory tract infections and ear disease (OR 3.06 95% CI [1.20–7.80]). Exposure to PM enhanced NTHi adhesion and invasion of epithelial cells and impaired IL-8 production. Exposure to geogenic PM may be contributing to the poor respiratory health of disadvantaged communities in arid environments where geogenic PM levels are high.

KW - Bacterial infection

KW - Child health

KW - Geogenic

KW - Indigenous

KW - Particulate matter

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