The complex regulatory architecture of Complement Receptor 2 (CR2) and the RCA gene cluster

Research output: ThesisDoctoral Thesis

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Abstract

Complement receptor 2 (CR2/CD21) is an important receptor expressed predominantly on B cells. Multiple lines of evidence have demonstrated a role for CR2 in the development of a chronic autoimmune disease called systemic lupus erythematosus (SLE). However, the contribution of CR2to the aetiology of SLE is not fully understood.

In this thesis, we revealed that CR2 is situated within complex transcriptional networks comprising of gene and environmental interactions in the RCA gene cluster. This work provides insight into the biology, disease mechanisms and evolution of the RCA.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Supervisors/Advisors
  • Ulgiati, Daniela, Supervisor
  • Quail, Liz, Supervisor
  • Abraham, Lawrie, Supervisor
Thesis sponsors
Award date14 Nov 2022
DOIs
Publication statusUnpublished - 2022

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