The complex regulatory architecture of Complement Receptor 2 (CR2) and the RCA gene cluster

Jess Cheng

doi:10.26182/egkf-4b13

The complex regulatory architecture of Complement Receptor 2 (CR2) and the RCA gene cluster

Jess Cheng

Research output: Thesis › Doctoral Thesis

114 Downloads (Pure)

Abstract

Complement receptor 2 (CR2/CD21) is an important receptor expressed predominantly on B cells. Multiple lines of evidence have demonstrated a role for CR2 in the development of a chronic autoimmune disease called systemic lupus erythematosus (SLE). However, the contribution of CR2to the aetiology of SLE is not fully understood.

In this thesis, we revealed that CR2 is situated within complex transcriptional networks comprising of gene and environmental interactions in the RCA gene cluster. This work provides insight into the biology, disease mechanisms and evolution of the RCA.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Ulgiati, Daniela, Supervisor Quail, Liz, Supervisor Abraham, Lawrie, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	14 Nov 2022
DOIs	https://doi.org/10.26182/egkf-4b13
Publication status	Unpublished - 2022

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10.26182/egkf-4b13

THESIS - DOCTOR OF PHILOSOPHY - CHENG Jess - 2022
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2 Article

Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer
Cheng, J., Clayton, J. S., Acemel, R. D., Zheng, Y., Taylor, R. L., Keleş, S., Franke, M., Boackle, S. A., Harley, J. B., Quail, E., Gómez-Skarmeta, J. L. & Ulgiati, D., 13 Jun 2022, In: Frontiers in Immunology. 13, p. 901747 901747.
Research output: Contribution to journal › Article › peer-review

Open Access
5 Citations (Scopus)
Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model
Ng, H. L., Taylor, R. L., Cheng, J., Abraham, L. J., Quail, E., Cruickshank, M. N. & Ulgiati, D., Dec 2020, In: Molecular Immunology. 128, p. 150-164 15 p.
Research output: Contribution to journal › Article › peer-review

Open Access
File
2 Citations (Scopus)

116 Downloads (Pure)

Cite this

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title = "The complex regulatory architecture of Complement Receptor 2 (CR2) and the RCA gene cluster",

abstract = "Complement receptor 2 (CR2/CD21) is an important receptor expressed predominantly on B cells. Multiple lines of evidence have demonstrated a role for CR2 in the development of a chronic autoimmune disease called systemic lupus erythematosus (SLE). However, the contribution of CR2to the aetiology of SLE is not fully understood.In this thesis, we revealed that CR2 is situated within complex transcriptional networks comprising of gene and environmental interactions in the RCA gene cluster. This work provides insight into the biology, disease mechanisms and evolution of the RCA.",

keywords = "RCA gene cluster, B cell, TADs, Enhancers, EBV, Complement receptor 2",

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year = "2022",

doi = "10.26182/egkf-4b13",

language = "English",

school = "The University of Western Australia",

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AB - Complement receptor 2 (CR2/CD21) is an important receptor expressed predominantly on B cells. Multiple lines of evidence have demonstrated a role for CR2 in the development of a chronic autoimmune disease called systemic lupus erythematosus (SLE). However, the contribution of CR2to the aetiology of SLE is not fully understood.In this thesis, we revealed that CR2 is situated within complex transcriptional networks comprising of gene and environmental interactions in the RCA gene cluster. This work provides insight into the biology, disease mechanisms and evolution of the RCA.

KW - RCA gene cluster

KW - B cell

KW - TADs

KW - Enhancers

KW - EBV

KW - Complement receptor 2

U2 - 10.26182/egkf-4b13

DO - 10.26182/egkf-4b13

M3 - Doctoral Thesis

ER -

The complex regulatory architecture of Complement Receptor 2 (CR2) and the RCA gene cluster

Abstract

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Regulatory Architecture of the RCA Gene Cluster Captures an Intragenic TAD Boundary, CTCF-Mediated Chromatin Looping and a Long-Range Intergenic Enhancer

Notch signaling induces a transcriptionally permissive state at the Complement C3d Receptor 2 (CR2) promoter in a pre-B cell model

Cite this