The Collaborative Cross, a community resource for the genetic analysis of complex traits

G.A. Churchill; D.C. Airey; H. Allayee; J.M. Angel; A.D. Attie; J. Beatty; W.D. Beavis; J.K. Belknap; B. Bennett; W. Berrettini; A. Bleich; M. Bogue; K.W. Broman; K.J. Buck; E. Buckler; M. Burmeister; E.J. Chesler; J.M. Cheverud; S. Clapcote; M.N. Cook; R.D. Cox; J.C. Crabbe; W.E. Crusio; A. Darvasi; C.F. Deschepper; R.W. Doerge; C.R. Farber; J. Forejt; D. Gaile; S.J. Garlow; H. Geiger; H. Gershenfeld; T. Gordon; J. Gu; W. Gu; G. De Haan; N.L. Hayes; C. Heller; H. Himmelbauer; R. Hitzemann; K. Hunter; H.C. Hsu; F.A. Iraqi; B. Ivandic; H.J. Jacob; R.C. Jansen; K.J. Jepsen; D.K. Johnson; T.E. Johnson; G. Kempermann; C. Kendziorski; M. Kotb; R.F. Kooy; B. Llamas; F. Lammert; J.M. Lassalle; P.R. Lowenstein; L. Lu; A. Lusis; K.F. Manly; R. Marcucio; D. Matthews; J.F. Medrano; D.R. Miller; G. Mittleman; B.A. Mock; J.S. Mogil; X. Montagutelli; Grant Morahan; D.G. Morris; R. Mott; J.H. Nadeau; H. Nagase; R.S. Nowakowski; B.F. O'Hara; A.V. Osadchuk; G.P. Page; B. Paigen; K. Paigen; A.A. Palmer; H.J. Pan; L. Peltonen-Palotie; J. Peirce; D. Pomp; M. Pravenec; D.R. Prows; Z. Qi; R.H. Reeves; J. Roder; G.D. Rosen; E.E. Schadt; L.C. Schalkwyk; Z. Seltzer; K. Shimomura; S. Shou; M.J. Sillanpaa; L.D. Siracusa; H.W. Snoeck; J.L. Spearow; K. Svenson; L.M. Tarantino; D. Threadgill; L.A. Toth; W. Valdar; F.P. De Villena; C. Warden; S. Whatley; R.W. Williams; T. Wiltshire; N. Yi; D. Zhang; M. Zhang; F. Zou

doi:10.1038/ng1104-1133

The Collaborative Cross, a community resource for the genetic analysis of complex traits

G.A. Churchill, D.C. Airey, H. Allayee, J.M. Angel, A.D. Attie, J. Beatty, W.D. Beavis, J.K. Belknap, B. Bennett, W. Berrettini, A. Bleich, M. Bogue, K.W. Broman, K.J. Buck, E. Buckler, M. Burmeister, E.J. Chesler, J.M. Cheverud, S. Clapcote, M.N. CookR.D. Cox, J.C. Crabbe, W.E. Crusio, A. Darvasi, C.F. Deschepper, R.W. Doerge, C.R. Farber, J. Forejt, D. Gaile, S.J. Garlow, H. Geiger, H. Gershenfeld, T. Gordon, J. Gu, W. Gu, G. De Haan, N.L. Hayes, C. Heller, H. Himmelbauer, R. Hitzemann, K. Hunter, H.C. Hsu, F.A. Iraqi, B. Ivandic, H.J. Jacob, R.C. Jansen, K.J. Jepsen, D.K. Johnson, T.E. Johnson, G. Kempermann, C. Kendziorski, M. Kotb, R.F. Kooy, B. Llamas, F. Lammert, J.M. Lassalle, P.R. Lowenstein, L. Lu, A. Lusis, K.F. Manly, R. Marcucio, D. Matthews, J.F. Medrano, D.R. Miller, G. Mittleman, B.A. Mock, J.S. Mogil, X. Montagutelli, Grant Morahan, D.G. Morris, R. Mott, J.H. Nadeau, H. Nagase, R.S. Nowakowski, B.F. O'Hara, A.V. Osadchuk, G.P. Page, B. Paigen, K. Paigen, A.A. Palmer, H.J. Pan, L. Peltonen-Palotie, J. Peirce, D. Pomp, M. Pravenec, D.R. Prows, Z. Qi, R.H. Reeves, J. Roder, G.D. Rosen, E.E. Schadt, L.C. Schalkwyk, Z. Seltzer, K. Shimomura, S. Shou, M.J. Sillanpaa, L.D. Siracusa, H.W. Snoeck, J.L. Spearow, K. Svenson, L.M. Tarantino, D. Threadgill, L.A. Toth, W. Valdar, F.P. De Villena, C. Warden, S. Whatley, R.W. Williams, T. Wiltshire, N. Yi, D. Zhang, M. Zhang, F. Zou

UWA Centre for Medical Research (affiliated with the Harry Perkins Institute of Medical Research)

Research output: Contribution to journal › Article › peer-review

913 Citations (Scopus)

Abstract

The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

Original language	English
Pages (from-to)	1133-1137
Journal	Nature Genetics
Volume	36
Issue number	11
DOIs	https://doi.org/10.1038/ng1104-1133
Publication status	Published - 2004

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ng1104-1133

Cite this

Churchill, G. A., Airey, D. C., Allayee, H., Angel, J. M., Attie, A. D., Beatty, J., Beavis, W. D., Belknap, J. K., Bennett, B., Berrettini, W., Bleich, A., Bogue, M., Broman, K. W., Buck, K. J., Buckler, E., Burmeister, M., Chesler, E. J., Cheverud, J. M., Clapcote, S., ... Zou, F. (2004). The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nature Genetics, 36(11), 1133-1137. https://doi.org/10.1038/ng1104-1133

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title = "The Collaborative Cross, a community resource for the genetic analysis of complex traits",

abstract = "The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.",

author = "G.A. Churchill and D.C. Airey and H. Allayee and J.M. Angel and A.D. Attie and J. Beatty and W.D. Beavis and J.K. Belknap and B. Bennett and W. Berrettini and A. Bleich and M. Bogue and K.W. Broman and K.J. Buck and E. Buckler and M. Burmeister and E.J. Chesler and J.M. Cheverud and S. Clapcote and M.N. Cook and R.D. Cox and J.C. Crabbe and W.E. Crusio and A. Darvasi and C.F. Deschepper and R.W. Doerge and C.R. Farber and J. Forejt and D. Gaile and S.J. Garlow and H. Geiger and H. Gershenfeld and T. Gordon and J. Gu and W. Gu and {De Haan}, G. and N.L. Hayes and C. Heller and H. Himmelbauer and R. Hitzemann and K. Hunter and H.C. Hsu and F.A. Iraqi and B. Ivandic and H.J. Jacob and R.C. Jansen and K.J. Jepsen and D.K. Johnson and T.E. Johnson and G. Kempermann and C. Kendziorski and M. Kotb and R.F. Kooy and B. Llamas and F. Lammert and J.M. Lassalle and P.R. Lowenstein and L. Lu and A. Lusis and K.F. Manly and R. Marcucio and D. Matthews and J.F. Medrano and D.R. Miller and G. Mittleman and B.A. Mock and J.S. Mogil and X. Montagutelli and Grant Morahan and D.G. Morris and R. Mott and J.H. Nadeau and H. Nagase and R.S. Nowakowski and B.F. O'Hara and A.V. Osadchuk and G.P. Page and B. Paigen and K. Paigen and A.A. Palmer and H.J. Pan and L. Peltonen-Palotie and J. Peirce and D. Pomp and M. Pravenec and D.R. Prows and Z. Qi and R.H. Reeves and J. Roder and G.D. Rosen and E.E. Schadt and L.C. Schalkwyk and Z. Seltzer and K. Shimomura and S. Shou and M.J. Sillanpaa and L.D. Siracusa and H.W. Snoeck and J.L. Spearow and K. Svenson and L.M. Tarantino and D. Threadgill and L.A. Toth and W. Valdar and {De Villena}, F.P. and C. Warden and S. Whatley and R.W. Williams and T. Wiltshire and N. Yi and D. Zhang and M. Zhang and F. Zou",

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Churchill, GA, Airey, DC, Allayee, H, Angel, JM, Attie, AD, Beatty, J, Beavis, WD, Belknap, JK, Bennett, B, Berrettini, W, Bleich, A, Bogue, M, Broman, KW, Buck, KJ, Buckler, E, Burmeister, M, Chesler, EJ, Cheverud, JM, Clapcote, S, Cook, MN, Cox, RD, Crabbe, JC, Crusio, WE, Darvasi, A, Deschepper, CF, Doerge, RW, Farber, CR, Forejt, J, Gaile, D, Garlow, SJ, Geiger, H, Gershenfeld, H, Gordon, T, Gu, J, Gu, W, De Haan, G, Hayes, NL, Heller, C, Himmelbauer, H, Hitzemann, R, Hunter, K, Hsu, HC, Iraqi, FA, Ivandic, B, Jacob, HJ, Jansen, RC, Jepsen, KJ, Johnson, DK, Johnson, TE, Kempermann, G, Kendziorski, C, Kotb, M, Kooy, RF, Llamas, B, Lammert, F, Lassalle, JM, Lowenstein, PR, Lu, L, Lusis, A, Manly, KF, Marcucio, R, Matthews, D, Medrano, JF, Miller, DR, Mittleman, G, Mock, BA, Mogil, JS, Montagutelli, X, Morahan, G, Morris, DG, Mott, R, Nadeau, JH, Nagase, H, Nowakowski, RS, O'Hara, BF, Osadchuk, AV, Page, GP, Paigen, B, Paigen, K, Palmer, AA, Pan, HJ, Peltonen-Palotie, L, Peirce, J, Pomp, D, Pravenec, M, Prows, DR, Qi, Z, Reeves, RH, Roder, J, Rosen, GD, Schadt, EE, Schalkwyk, LC, Seltzer, Z, Shimomura, K, Shou, S, Sillanpaa, MJ, Siracusa, LD, Snoeck, HW, Spearow, JL, Svenson, K, Tarantino, LM, Threadgill, D, Toth, LA, Valdar, W, De Villena, FP, Warden, C, Whatley, S, Williams, RW, Wiltshire, T, Yi, N, Zhang, D, Zhang, M & Zou, F 2004, 'The Collaborative Cross, a community resource for the genetic analysis of complex traits', Nature Genetics, vol. 36, no. 11, pp. 1133-1137. https://doi.org/10.1038/ng1104-1133

TY - JOUR

T1 - The Collaborative Cross, a community resource for the genetic analysis of complex traits

AU - Churchill, G.A.

AU - Airey, D.C.

AU - Allayee, H.

AU - Angel, J.M.

AU - Attie, A.D.

AU - Beatty, J.

AU - Beavis, W.D.

AU - Belknap, J.K.

AU - Bennett, B.

AU - Berrettini, W.

AU - Bleich, A.

AU - Bogue, M.

AU - Broman, K.W.

AU - Buck, K.J.

AU - Buckler, E.

AU - Burmeister, M.

AU - Chesler, E.J.

AU - Cheverud, J.M.

AU - Clapcote, S.

AU - Cook, M.N.

AU - Cox, R.D.

AU - Crabbe, J.C.

AU - Crusio, W.E.

AU - Darvasi, A.

AU - Deschepper, C.F.

AU - Doerge, R.W.

AU - Farber, C.R.

AU - Forejt, J.

AU - Gaile, D.

AU - Garlow, S.J.

AU - Geiger, H.

AU - Gershenfeld, H.

AU - Gordon, T.

AU - Gu, J.

AU - Gu, W.

AU - De Haan, G.

AU - Hayes, N.L.

AU - Heller, C.

AU - Himmelbauer, H.

AU - Hitzemann, R.

AU - Hunter, K.

AU - Hsu, H.C.

AU - Iraqi, F.A.

AU - Ivandic, B.

AU - Jacob, H.J.

AU - Jansen, R.C.

AU - Jepsen, K.J.

AU - Johnson, D.K.

AU - Johnson, T.E.

AU - Kempermann, G.

AU - Kendziorski, C.

AU - Kotb, M.

AU - Kooy, R.F.

AU - Llamas, B.

AU - Lammert, F.

AU - Lassalle, J.M.

AU - Lowenstein, P.R.

AU - Lu, L.

AU - Lusis, A.

AU - Manly, K.F.

AU - Marcucio, R.

AU - Matthews, D.

AU - Medrano, J.F.

AU - Miller, D.R.

AU - Mittleman, G.

AU - Mock, B.A.

AU - Mogil, J.S.

AU - Montagutelli, X.

AU - Morahan, Grant

AU - Morris, D.G.

AU - Mott, R.

AU - Nadeau, J.H.

AU - Nagase, H.

AU - Nowakowski, R.S.

AU - O'Hara, B.F.

AU - Osadchuk, A.V.

AU - Page, G.P.

AU - Paigen, B.

AU - Paigen, K.

AU - Palmer, A.A.

AU - Pan, H.J.

AU - Peltonen-Palotie, L.

AU - Peirce, J.

AU - Pomp, D.

AU - Pravenec, M.

AU - Prows, D.R.

AU - Qi, Z.

AU - Reeves, R.H.

AU - Roder, J.

AU - Rosen, G.D.

AU - Schadt, E.E.

AU - Schalkwyk, L.C.

AU - Seltzer, Z.

AU - Shimomura, K.

AU - Shou, S.

AU - Sillanpaa, M.J.

AU - Siracusa, L.D.

AU - Snoeck, H.W.

AU - Spearow, J.L.

AU - Svenson, K.

AU - Tarantino, L.M.

AU - Threadgill, D.

AU - Toth, L.A.

AU - Valdar, W.

AU - De Villena, F.P.

AU - Warden, C.

AU - Whatley, S.

AU - Williams, R.W.

AU - Wiltshire, T.

AU - Yi, N.

AU - Zhang, D.

AU - Zhang, M.

AU - Zou, F.

PY - 2004

Y1 - 2004

N2 - The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

AB - The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.

U2 - 10.1038/ng1104-1133

DO - 10.1038/ng1104-1133

M3 - Article

C2 - 15514660

SN - 1061-4036

VL - 36

SP - 1133

EP - 1137

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -

The Collaborative Cross, a community resource for the genetic analysis of complex traits

Abstract

UN SDGs

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