The clinical significance of HLA antibodies detected by solid phase assay In renal transplant recipients

Samantha Jane Fidler

    Research output: ThesisDoctoral Thesis

    538 Downloads (Pure)

    Abstract

    Kidney transplantation is the therapy of choice for end stage renal failure. One of the major immunological hurdles in transplantation is the presence of pre-formed antibodies in the recipient directed against donor HLA antigens. Donor specific anti-HLA antibodies are associated with allograft rejection and poor long term graft outcome. In recent years, the detection of anti-HLA antibodies has evolved from the relatively insensitive lymphocytotoxic crossmatch to the more sensitive solid phase assays including ELISA and Luminex bead assays.
    This thesis investigates the clinical significance of anti-HLA antibodies detected by Luminex single antigen bead assay on renal transplant outcome.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date21 Dec 2016
    Publication statusUnpublished - 2016

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