The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

D. Apostolovic; S. Sánchez-Vidaurre; K. Waden; M. Curin; J. Grundström; G. Gafvelin; T. Cirkovic Velickovic; H. Grönlund; Wayne Thomas; R. Valenta; C. Hamsten; M. Van Hage

doi:10.1111/all.12955

The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

D. Apostolovic, S. Sánchez-Vidaurre, K. Waden, M. Curin, J. Grundström, G. Gafvelin, T. Cirkovic Velickovic, H. Grönlund, Wayne Thomas, R. Valenta, C. Hamsten, M. Van Hage

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Abstract

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons LtdWe investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat- but also in dog-allergic patients.

Original language	English
Pages (from-to)	1490-1495
Number of pages	6
Journal	Allergy: European Journal of Allergy and Clinical Immunology
Volume	71
Issue number	10
DOIs	https://doi.org/10.1111/all.12955
Publication status	Published - 1 Oct 2016

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Apostolovic, D., Sánchez-Vidaurre, S., Waden, K., Curin, M., Grundström, J., Gafvelin, G., Cirkovic Velickovic, T., Grönlund, H., Thomas, W., Valenta, R., Hamsten, C., & Van Hage, M. (2016). The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. Allergy: European Journal of Allergy and Clinical Immunology, 71(10), 1490-1495. https://doi.org/10.1111/all.12955

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title = "The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1",

abstract = "{\textcopyright} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons LtdWe investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat- but also in dog-allergic patients.",

author = "D. Apostolovic and S. S{\'a}nchez-Vidaurre and K. Waden and M. Curin and J. Grundstr{\"o}m and G. Gafvelin and {Cirkovic Velickovic}, T. and H. Gr{\"o}nlund and Wayne Thomas and R. Valenta and C. Hamsten and {Van Hage}, M.",

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Apostolovic, D, Sánchez-Vidaurre, S, Waden, K, Curin, M, Grundström, J, Gafvelin, G, Cirkovic Velickovic, T, Grönlund, H, Thomas, W, Valenta, R, Hamsten, C & Van Hage, M 2016, 'The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1', Allergy: European Journal of Allergy and Clinical Immunology, vol. 71, no. 10, pp. 1490-1495. https://doi.org/10.1111/all.12955

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T1 - The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

AU - Apostolovic, D.

AU - Sánchez-Vidaurre, S.

AU - Waden, K.

AU - Curin, M.

AU - Grundström, J.

AU - Gafvelin, G.

AU - Cirkovic Velickovic, T.

AU - Grönlund, H.

AU - Thomas, Wayne

AU - Valenta, R.

AU - Hamsten, C.

AU - Van Hage, M.

PY - 2016/10/1

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N2 - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons LtdWe investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat- but also in dog-allergic patients.

AB - © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons LtdWe investigated the prevalence of sensitization to the cat lipocalin Fel d 7 among 140 cat-sensitized Swedish patients and elucidated its allergenic activity and cross-reactivity with the dog lipocalin Can f 1. Sixty-five of 140 patients had IgE to rFel d 7 whereof 60 also had IgE to rCan f 1. A moderate correlation between IgE levels to rFel d 7 and rCan f 1 was found. rFel d 7 activated basophils in vitro and inhibited IgE binding to rCan f 1 in 4 of 13 patients, whereas rCan f 1 inhibited IgE binding to rFel d 7 in 7 of 13 patients. Fel d 7 and Can f 1 showed high similarities in protein structure and epitopes in common were found using cross-reactive antisera. Fel d 7 is a common allergen in a Swedish cat-sensitized population that cross-reacts with Can f 1, and may contribute to symptoms in cat- but also in dog-allergic patients.

U2 - 10.1111/all.12955

DO - 10.1111/all.12955

M3 - Article

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SN - 0105-4538

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SP - 1490

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JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 10

ER -

The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1

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