New geochronological data provide evidence for Permo-Triassic low-sulfidation epithermal gold-silver mineralization in the Cordillera Frontal, Argentina. The U-Pb sensitive high-resolution ion microprobe (SHRIMP) analyses on zircons and titanite gave the following results: (1) andesite and rhyolite volcanic host rocks of the Casposo Au-Ag deposit yielded a range of ages between 267.1 ± 0.7 and 241.7 ± 2.2 Ma; (2) two composite plutons located near Casposo yielded ages of 268.2 ± 1.5 and 265.1 ± 1.5 Ma for the Colorado syenogranite-granite pluton and 266.6 ± 1.4 and 254.0 ± 2.4 Ma for the Casposo granodiorite-tonalite pluton; (3) a trachyandesite dike emplaced at 265.7 ± 1.2 Ma that is crosscut by mineralized quartz-adularia-calcite-gold veins in the Kamila East area; (4) felsite intrusions, interpreted to be temporally related to the emplacement of mineralized veins at 261.1 ± 3.5 Ma; and (5) composite rhyolite/andesite dikes that crosscut all other lithostratigraphic units and mineralized veins at 238.4 ± 1.6 Ma. The 40Ar/39Ar dates on hydrothermal adularia within quartz-adularia-calcite-gold veins of the Casposo deposit revealed at least three, likely discreet, hydrothermal fluid pulses and associated periods of vein formation during extensional events between 280-274, 262-258, and 250-246 Ma. Relative and absolute timing of volcanic host rocks, plutons, postmineralization felsic dikes, and gold-bearing veins of the Casposo epithermal vein system suggest the presence of significant Permian (Cisuralian)Lower Triassic low-sulfidation epithermal-style gold-silver mineralization at the eastern flank of the Cordillera Principal in Argentina. The existence of this epithermal Au-Ag system opens the potential for a significant magmatic-hydrothermal system in a part of the Andes that previously was considered to be of low prospectivity.