The Cardiovascular and Metabolic Health Benefits of Dietary Nitrate

Grace Liu

doi:10.26182/y6jz-xm66

The Cardiovascular and Metabolic Health Benefits of Dietary Nitrate

Grace Liu

School of Biomedical Sciences

Research output: Thesis › Doctoral Thesis

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Abstract

Cardiovascular disease (CVD) remains a major contributor to health care expenses. Studies in both humans and animals have demonstrated that increased intake of dietary nitrate can improve endothelial function and provide protection against the development of CVD. This study investigated whether long-term dietary nitrate supplementation could attenuate the progression of CVD and associated metabolic disease. The findings have for the first time, demonstrated that nitrate can potentially prevent the progression of atherosclerosis and CVD. Although the mechanisms have not been fully elucidated, this appears to be in part due to enhanced endogenous and exogenous NO bioavailability and activity.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Ward, Natalie, Supervisor Croft, Kevin, Supervisor Mori, Trevor, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	8 Nov 2022
DOIs	https://doi.org/10.26182/y6jz-xm66
Publication status	Unpublished - 2022

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.26182/y6jz-xm66

THESIS - DOCTOR OF PHILOSOPHY - LIU Yang Grace - 2022
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2 Article
1 Review article

Beneficial effects of inorganic nitrate in non-alcoholic fatty liver disease
Liu, Y., Croft, K. D., Caparros-Martin, J., O'Gara, F., Mori, T. A. & Ward, N. C., 30 Oct 2021, In: Archives of Biochemistry and Biophysics. 711, 109032.
Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus)
Chronic nitrite treatment activates adenosine monophosphate-activated protein kinase-endothelial nitric oxide synthase pathway in human aortic endothelial cells
Liu, Y., Croft, K. D., Hodgson, J. M., Mori, T. & Ward, N. C., May 2021, In: Journal of Functional Foods. 80, 104447.
Research output: Contribution to journal › Article › peer-review

Open Access
3 Citations (Scopus)
Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases
Liu, G., Croft, K., Hodgson, J., Mori, T. & Ward, N., 1 Mar 2020, In: Nitric Oxide - Biology and Chemistry. 96, p. 35-43 9 p.
Research output: Contribution to journal › Review article › peer-review

31 Citations (Scopus)

Cite this

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title = "The Cardiovascular and Metabolic Health Benefits of Dietary Nitrate",

abstract = "Cardiovascular disease (CVD) remains a major contributor to health care expenses. Studies in both humans and animals have demonstrated that increased intake of dietary nitrate can improve endothelial function and provide protection against the development of CVD. This study investigated whether long-term dietary nitrate supplementation could attenuate the progression of CVD and associated metabolic disease. The findings have for the first time, demonstrated that nitrate can potentially prevent the progression of atherosclerosis and CVD. Although the mechanisms have not been fully elucidated, this appears to be in part due to enhanced endogenous and exogenous NO bioavailability and activity.",

keywords = "cardiovascular disease, nonalcoholic fatty liver disease, nitrite, nitrate, ApoE-/- mice",

author = "Grace Liu",

year = "2022",

doi = "10.26182/y6jz-xm66",

language = "English",

school = "The University of Western Australia",

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AB - Cardiovascular disease (CVD) remains a major contributor to health care expenses. Studies in both humans and animals have demonstrated that increased intake of dietary nitrate can improve endothelial function and provide protection against the development of CVD. This study investigated whether long-term dietary nitrate supplementation could attenuate the progression of CVD and associated metabolic disease. The findings have for the first time, demonstrated that nitrate can potentially prevent the progression of atherosclerosis and CVD. Although the mechanisms have not been fully elucidated, this appears to be in part due to enhanced endogenous and exogenous NO bioavailability and activity.

KW - cardiovascular disease

KW - nonalcoholic fatty liver disease

KW - nitrite

KW - nitrate

KW - ApoE-/- mice

U2 - 10.26182/y6jz-xm66

DO - 10.26182/y6jz-xm66

M3 - Doctoral Thesis

ER -

The Cardiovascular and Metabolic Health Benefits of Dietary Nitrate

Abstract

UN SDGs

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Research output

Beneficial effects of inorganic nitrate in non-alcoholic fatty liver disease

Chronic nitrite treatment activates adenosine monophosphate-activated protein kinase-endothelial nitric oxide synthase pathway in human aortic endothelial cells

Mechanisms of the protective effects of nitrate and nitrite in cardiovascular and metabolic diseases

Cite this