Projects per year
Cardiovascular disease is the leading cause of death in the Western world. The incidence of cardiovascular disease is predicted to further rise with the increase in obesity and diabetes and with the aging population. Even though the survival rate from ischaemic heart disease has improved over the past 30 years, many patients progress to a chronic pathological condition, known as cardiac hypertrophy that is associated with an increase in morbidity and mortality. Reactive oxygen species (ROS) and calcium play an essential role in mediating cardiac hypertrophy. The L-type calcium channel is the main route for calcium influx into cardiac myocytes. There is now good evidence for a direct role for the L-type calcium channel in the development of cardiac hypertrophy. Cysteines on the channel are targets for redox modification and glutathionylation of the channel can modulate the function of the channel protein leading to the onset of pathology. The cysteine responsible for modification of L-type calcium channel function has now been identified. Detailed understanding of the role of cysteines as possible targets during oxidative stress may assist in designing therapy to prevent the development of hypertrophy and heart failure.
|Number of pages||9|
|Journal||Clinical and Experimental Pharmacology and Physiology|
|Publication status||Published - 1 Dec 2017|
FingerprintDive into the research topics of 'The cardiac L-type calcium channel alpha subunit is a target for direct redox modification during oxidative stress—the role of cysteine residues in the alpha interacting domain'. Together they form a unique fingerprint.
- 3 Finished
NHMRC Research Fellowships - Hool
National Health & Medical Research Council NHMRC
1/01/11 → 31/12/16
Determining how Calcium Regulates Mitochondrial Function in Models of Cardiomyopathy.
1/01/10 → 31/12/14