The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits

Rebecca Webster; Nicole Warrington; M.N. Weedon; A.T. Hattersley; Pamela Mccaskie; John Beilby; Lyle Palmer; T.M. Frayling

doi:10.1007/s00125-008-1175-9

The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits

Rebecca Webster, Nicole Warrington, M.N. Weedon, A.T. Hattersley, Pamela Mccaskie, John Beilby, Lyle Palmer, T.M. Frayling

Centre for Genetic Origins of Health and Diseases

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Aims/hypothesisCommon genetic variants influence plasma triacylglycerol, HDL-cholesterol (HDL-C) and glucose levels in cross-sectional studies. However, the longitudinal effects of these established variants have not been studied. Our aim was to examine the longitudinal associations of four such variants in the apolipoprotein A-V (APOA5), lipoprotein lipase (LPL), and glucokinase (GCK) genes with fasting glucose or lipid levels.MethodsThe individuals analysed were participants in the Busselton Health Survey (n = 4,554). Cross-sectional analyses of family data used the total association test. Longitudinal association analyses of unrelated participant data (n = 2,864) used linear mixed-effects models.ResultsThe findings of cross-sectional association analyses replicated those of previous studies. We observed associations of the G and C alleles at the APOA5 single nucleotide polymorphisms (SNPs) rs662799 and rs3135506 with raised triacylglycerol levels (p = 0.0003 and p

Original language	English
Pages (from-to)	106-114
Journal	Diabetologia
Volume	52
Issue number	1
DOIs	https://doi.org/10.1007/s00125-008-1175-9
Publication status	Published - 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00125-008-1175-9

Cite this

@article{645c2a8549e144a99d54056e28cbf832,

title = "The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits",

abstract = "Aims/hypothesisCommon genetic variants influence plasma triacylglycerol, HDL-cholesterol (HDL-C) and glucose levels in cross-sectional studies. However, the longitudinal effects of these established variants have not been studied. Our aim was to examine the longitudinal associations of four such variants in the apolipoprotein A-V (APOA5), lipoprotein lipase (LPL), and glucokinase (GCK) genes with fasting glucose or lipid levels.MethodsThe individuals analysed were participants in the Busselton Health Survey (n = 4,554). Cross-sectional analyses of family data used the total association test. Longitudinal association analyses of unrelated participant data (n = 2,864) used linear mixed-effects models.ResultsThe findings of cross-sectional association analyses replicated those of previous studies. We observed associations of the G and C alleles at the APOA5 single nucleotide polymorphisms (SNPs) rs662799 and rs3135506 with raised triacylglycerol levels (p = 0.0003 and p ",

author = "Rebecca Webster and Nicole Warrington and M.N. Weedon and A.T. Hattersley and Pamela Mccaskie and John Beilby and Lyle Palmer and T.M. Frayling",

year = "2009",

doi = "10.1007/s00125-008-1175-9",

language = "English",

volume = "52",

pages = "106--114",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

number = "1",

}

TY - JOUR

T1 - The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits

AU - Webster, Rebecca

AU - Warrington, Nicole

AU - Weedon, M.N.

AU - Hattersley, A.T.

AU - Mccaskie, Pamela

AU - Beilby, John

AU - Palmer, Lyle

AU - Frayling, T.M.

PY - 2009

Y1 - 2009

N2 - Aims/hypothesisCommon genetic variants influence plasma triacylglycerol, HDL-cholesterol (HDL-C) and glucose levels in cross-sectional studies. However, the longitudinal effects of these established variants have not been studied. Our aim was to examine the longitudinal associations of four such variants in the apolipoprotein A-V (APOA5), lipoprotein lipase (LPL), and glucokinase (GCK) genes with fasting glucose or lipid levels.MethodsThe individuals analysed were participants in the Busselton Health Survey (n = 4,554). Cross-sectional analyses of family data used the total association test. Longitudinal association analyses of unrelated participant data (n = 2,864) used linear mixed-effects models.ResultsThe findings of cross-sectional association analyses replicated those of previous studies. We observed associations of the G and C alleles at the APOA5 single nucleotide polymorphisms (SNPs) rs662799 and rs3135506 with raised triacylglycerol levels (p = 0.0003 and p

AB - Aims/hypothesisCommon genetic variants influence plasma triacylglycerol, HDL-cholesterol (HDL-C) and glucose levels in cross-sectional studies. However, the longitudinal effects of these established variants have not been studied. Our aim was to examine the longitudinal associations of four such variants in the apolipoprotein A-V (APOA5), lipoprotein lipase (LPL), and glucokinase (GCK) genes with fasting glucose or lipid levels.MethodsThe individuals analysed were participants in the Busselton Health Survey (n = 4,554). Cross-sectional analyses of family data used the total association test. Longitudinal association analyses of unrelated participant data (n = 2,864) used linear mixed-effects models.ResultsThe findings of cross-sectional association analyses replicated those of previous studies. We observed associations of the G and C alleles at the APOA5 single nucleotide polymorphisms (SNPs) rs662799 and rs3135506 with raised triacylglycerol levels (p = 0.0003 and p

U2 - 10.1007/s00125-008-1175-9

DO - 10.1007/s00125-008-1175-9

M3 - Article

C2 - 19018513

SN - 0012-186X

VL - 52

SP - 106

EP - 114

JO - Diabetologia

JF - Diabetologia

IS - 1

ER -

The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this