The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis

Daan Caudri; Lidija Turkovic; Jolyn Ng; Nicholas H. de Klerk; Tim Rosenow; Graham L. Hall; Sarath C. Ranganathan; Peter D. Sly; Stephen M. Stick

doi:10.1016/j.jcf.2017.12.002

The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis

Daan Caudri, Lidija Turkovic, Jolyn Ng, Nicholas H. de Klerk, Tim Rosenow, Graham L. Hall, Sarath C. Ranganathan, Peter D. Sly, Stephen M. Stick

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4 years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5–7 years were investigated. Models were adjusted for multiple markers of disease severity at baseline. Results: De novo S. aureus acquisition at 3-years-old (n/N = 12/122) was associated with increased bronchiectasis score at age 5–6 years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF_25–75 at age 5–7 years, but not with FEV₁-%-predicted. Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF_25–75 in children with CF.

Original language	English
Pages (from-to)	462-469
Number of pages	8
Journal	Journal of Cystic Fibrosis
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/j.jcf.2017.12.002
Publication status	Published - 1 Jul 2018

Fingerprint

Bronchiectasis

Cystic Fibrosis

Staphylococcus aureus

Tomography

Spirometry

Bronchoscopy

Bronchoalveolar Lavage

Lung Diseases

Cohort Studies

Thorax

Lung

Cite this

Caudri, D., Turkovic, L., Ng, J., de Klerk, N. H., Rosenow, T., Hall, G. L., ... Stick, S. M. (2018). The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis. Journal of Cystic Fibrosis, 17(4), 462-469. https://doi.org/10.1016/j.jcf.2017.12.002

Caudri, Daan ; Turkovic, Lidija ; Ng, Jolyn ; de Klerk, Nicholas H. ; Rosenow, Tim ; Hall, Graham L. ; Ranganathan, Sarath C. ; Sly, Peter D. ; Stick, Stephen M. / The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis. In: Journal of Cystic Fibrosis. 2018 ; Vol. 17, No. 4. pp. 462-469.

@article{cbc2d8fa1e894e4c9e3eac42a932d95f,

title = "The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis",

abstract = "Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4 years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5–7 years were investigated. Models were adjusted for multiple markers of disease severity at baseline. Results: De novo S. aureus acquisition at 3-years-old (n/N = 12/122) was associated with increased bronchiectasis score at age 5–6 years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF25–75 at age 5–7 years, but not with FEV1-{\%}-predicted. Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25–75 in children with CF.",

keywords = "CT scan, Infection and inflammation, Lung function, Structural lung damage",

author = "Daan Caudri and Lidija Turkovic and Jolyn Ng and {de Klerk}, {Nicholas H.} and Tim Rosenow and Hall, {Graham L.} and Ranganathan, {Sarath C.} and Sly, {Peter D.} and Stick, {Stephen M.}",

year = "2018",

month = "7",

day = "1",

doi = "10.1016/j.jcf.2017.12.002",

language = "English",

volume = "17",

pages = "462--469",

journal = "Journal of Cystic Fibrosis",

issn = "1569-1993",

publisher = "Elsevier",

number = "4",

}

Caudri, D, Turkovic, L, Ng, J, de Klerk, NH, Rosenow, T, Hall, GL, Ranganathan, SC, Sly, PD & Stick, SM 2018, 'The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis' Journal of Cystic Fibrosis, vol. 17, no. 4, pp. 462-469. https://doi.org/10.1016/j.jcf.2017.12.002

The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis. / Caudri, Daan; Turkovic, Lidija; Ng, Jolyn; de Klerk, Nicholas H.; Rosenow, Tim; Hall, Graham L.; Ranganathan, Sarath C.; Sly, Peter D.; Stick, Stephen M.

In: Journal of Cystic Fibrosis, Vol. 17, No. 4, 01.07.2018, p. 462-469.

Research output: Contribution to journal › Article

TY - JOUR

T1 - The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis

AU - Caudri, Daan

AU - Turkovic, Lidija

AU - Ng, Jolyn

AU - de Klerk, Nicholas H.

AU - Rosenow, Tim

AU - Hall, Graham L.

AU - Ranganathan, Sarath C.

AU - Sly, Peter D.

AU - Stick, Stephen M.

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4 years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5–7 years were investigated. Models were adjusted for multiple markers of disease severity at baseline. Results: De novo S. aureus acquisition at 3-years-old (n/N = 12/122) was associated with increased bronchiectasis score at age 5–6 years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF25–75 at age 5–7 years, but not with FEV1-%-predicted. Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25–75 in children with CF.

AB - Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4 years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5–7 years were investigated. Models were adjusted for multiple markers of disease severity at baseline. Results: De novo S. aureus acquisition at 3-years-old (n/N = 12/122) was associated with increased bronchiectasis score at age 5–6 years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF25–75 at age 5–7 years, but not with FEV1-%-predicted. Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25–75 in children with CF.

KW - CT scan

KW - Infection and inflammation

KW - Lung function

KW - Structural lung damage

UR - http://www.scopus.com/inward/record.url?scp=85038878751&partnerID=8YFLogxK

U2 - 10.1016/j.jcf.2017.12.002

DO - 10.1016/j.jcf.2017.12.002

M3 - Article

VL - 17

SP - 462

EP - 469

JO - Journal of Cystic Fibrosis