TY - JOUR
T1 - The association between Staphylococcus aureus and subsequent bronchiectasis in children with cystic fibrosis
AU - Caudri, Daan
AU - Turkovic, Lidija
AU - Ng, Jolyn
AU - de Klerk, Nicholas H.
AU - Rosenow, Tim
AU - Hall, Graham L.
AU - Ranganathan, Sarath C.
AU - Sly, Peter D.
AU - Stick, Stephen M.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4 years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5–7 years were investigated. Models were adjusted for multiple markers of disease severity at baseline. Results: De novo S. aureus acquisition at 3-years-old (n/N = 12/122) was associated with increased bronchiectasis score at age 5–6 years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF25–75 at age 5–7 years, but not with FEV1-%-predicted. Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25–75 in children with CF.
AB - Background: Staphylococcus aureus (S. aureus) may be related to more rapid progression of cystic fibrosis (CF) lung disease. Methods: In the AREST CF cohort study, children diagnosed with CF undergo annual bronchoscopies with bronchoalveolar lavage and ultra-low-dose, chest computed tomography (CT) up to 6-years-old. Spirometry was assessed 3-monthly from the age of 4 years. Associations between de novo S. aureus acquisition before school age and CT and lung function at ages 5–7 years were investigated. Models were adjusted for multiple markers of disease severity at baseline. Results: De novo S. aureus acquisition at 3-years-old (n/N = 12/122) was associated with increased bronchiectasis score at age 5–6 years. This association decreased but remained significant after adjustment for confounders. S. aureus at 3 was associated with significantly reduced FEF25–75 at age 5–7 years, but not with FEV1-%-predicted. Conclusion: De novo S. aureus acquisition at age 3 is associated with later bronchiectasis and FEF25–75 in children with CF.
KW - CT scan
KW - Infection and inflammation
KW - Lung function
KW - Structural lung damage
UR - http://www.scopus.com/inward/record.url?scp=85038878751&partnerID=8YFLogxK
U2 - 10.1016/j.jcf.2017.12.002
DO - 10.1016/j.jcf.2017.12.002
M3 - Article
C2 - 29274943
AN - SCOPUS:85038878751
VL - 17
SP - 462
EP - 469
JO - Journal of Cystic Fibrosis
JF - Journal of Cystic Fibrosis
SN - 1569-1993
IS - 4
ER -