The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease

Mohammed Eslam; Jian-Gao Fan; Ming-Lung Yu; Vincent Wai-Sun Wong; Ian Homer Cua; Chun-Jen Liu; Tawesak Tanwandee; Rino Gani; Wai-Kay Seto; Shahinul Alam; Dan Yock Young; Saeed Hamid; Ming-Hua Zheng; Takumi Kawaguchi; Wah-Kheong Chan; Diana Payawal; Soek-Siam Tan; George Boon-bee Goh; Simone I. Strasser; Hang Dao Viet; Jia-Horng Kao; Won Kim; Seung Up Kim; Shelley E. Keating; Yusuf Yilmaz; Lubna Kamani; Chia-Chi Wang; Yasser Fouad; Zaigham Abbas; Sombat Treeprasertsuk; Kessarin Thanapirom; Mamun Al Mahtab; Undram Lkhagvaa; Oidov Baatarkhuu; Ashok Kumar Choudhury; Catherine A. M. Stedman; Abhijit Chowdhury; A. Kadir Dokmeci; Fu-Sheng Wang; Han-Chieh Lin; Jee-Fu Huang; Jess Howell; Jidong Jia; Mohamed Alboraie; Stuart K. Roberts; Masato Yoneda; Hasmik Ghazinian; Aram Mirijanyan; Yuemin Nan; Cosmas Rinaldi Adithya Lesmana; Leon A. Adams; Gamal Shiha; Manoj Kumar; Necati Oermeci; Lai Wei; George Lau; Masao Omata; Shiv K. Sarin; Jacob George

doi:10.1007/s12072-024-10774-3

The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease

Mohammed Eslam, Jian-Gao Fan, Ming-Lung Yu, Vincent Wai-Sun Wong, Ian Homer Cua, Chun-Jen Liu, Tawesak Tanwandee, Rino Gani, Wai-Kay Seto, Shahinul Alam, Dan Yock Young, Saeed Hamid, Ming-Hua Zheng, Takumi Kawaguchi, Wah-Kheong Chan, Diana Payawal, Soek-Siam Tan, George Boon-bee Goh, Simone I. Strasser, Hang Dao VietJia-Horng Kao, Won Kim, Seung Up Kim, Shelley E. Keating, Yusuf Yilmaz, Lubna Kamani, Chia-Chi Wang, Yasser Fouad, Zaigham Abbas, Sombat Treeprasertsuk, Kessarin Thanapirom, Mamun Al Mahtab, Undram Lkhagvaa, Oidov Baatarkhuu, Ashok Kumar Choudhury, Catherine A. M. Stedman, Abhijit Chowdhury, A. Kadir Dokmeci, Fu-Sheng Wang, Han-Chieh Lin, Jee-Fu Huang, Jess Howell, Jidong Jia, Mohamed Alboraie, Stuart K. Roberts, Masato Yoneda, Hasmik Ghazinian, Aram Mirijanyan, Yuemin Nan, Cosmas Rinaldi Adithya Lesmana, Leon A. Adams, Gamal Shiha, Manoj Kumar, Necati Oermeci, Lai Wei, George Lau, Masao Omata, Shiv K. Sarin, Jacob George

Internal Medicine

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Abstract

Metabolic dysfunction-associated fatty liver disease (MAFLD) affects over one-fourth of the global adult population and is the leading cause of liver disease worldwide. To address this, the Asian Pacific Association for the Study of the Liver (APASL) has created clinical practice guidelines focused on MAFLD. The guidelines cover various aspects of the disease, such as its epidemiology, diagnosis, screening, assessment, and treatment. The guidelines aim to advance clinical practice, knowledge, and research on MAFLD, particularly in special groups. The guidelines are designed to advance clinical practice, to provide evidence-based recommendations to assist healthcare stakeholders in decision-making and to improve patient care and disease awareness. The guidelines take into account the burden of clinical management for the healthcare sector.

Original language	English
Article number	e070189
Pages (from-to)	261-301
Number of pages	41
Journal	Hepatology International
Volume	19
Issue number	2
Early online date	27 Feb 2025
DOIs	https://doi.org/10.1007/s12072-024-10774-3
Publication status	Published - Apr 2025

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Eslam, M., Fan, J.-G., Yu, M.-L., Wong, V. W.-S., Cua, I. H., Liu, C.-J., Tanwandee, T., Gani, R., Seto, W.-K., Alam, S., Young, D. Y., Hamid, S., Zheng, M.-H., Kawaguchi, T., Chan, W.-K., Payawal, D., Tan, S.-S., Goh, G. B., Strasser, S. I., ... George, J. (2025). The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease. Hepatology International, 19(2), 261-301. Article e070189. https://doi.org/10.1007/s12072-024-10774-3

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title = "The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease",

abstract = "Metabolic dysfunction-associated fatty liver disease (MAFLD) affects over one-fourth of the global adult population and is the leading cause of liver disease worldwide. To address this, the Asian Pacific Association for the Study of the Liver (APASL) has created clinical practice guidelines focused on MAFLD. The guidelines cover various aspects of the disease, such as its epidemiology, diagnosis, screening, assessment, and treatment. The guidelines aim to advance clinical practice, knowledge, and research on MAFLD, particularly in special groups. The guidelines are designed to advance clinical practice, to provide evidence-based recommendations to assist healthcare stakeholders in decision-making and to improve patient care and disease awareness. The guidelines take into account the burden of clinical management for the healthcare sector.",

keywords = "Chronic hepatitis-c, Nonalcoholic steatohepatitis nash, Hepatocellular-carcinoma patients, B-virus infection, Vitamin-e, Bariatric surgery, Risk-factors, Portal-hypertension, Multidisciplinary approach, Calorie restriction",

author = "Mohammed Eslam and Jian-Gao Fan and Ming-Lung Yu and Wong, \{Vincent Wai-Sun\} and Cua, \{Ian Homer\} and Chun-Jen Liu and Tawesak Tanwandee and Rino Gani and Wai-Kay Seto and Shahinul Alam and Young, \{Dan Yock\} and Saeed Hamid and Ming-Hua Zheng and Takumi Kawaguchi and Wah-Kheong Chan and Diana Payawal and Soek-Siam Tan and Goh, \{George Boon-bee\} and Strasser, \{Simone I.\} and Viet, \{Hang Dao\} and Jia-Horng Kao and Won Kim and Kim, \{Seung Up\} and Keating, \{Shelley E.\} and Yusuf Yilmaz and Lubna Kamani and Chia-Chi Wang and Yasser Fouad and Zaigham Abbas and Sombat Treeprasertsuk and Kessarin Thanapirom and \{Al Mahtab\}, Mamun and Undram Lkhagvaa and Oidov Baatarkhuu and Choudhury, \{Ashok Kumar\} and Stedman, \{Catherine A. M.\} and Abhijit Chowdhury and Dokmeci, \{A. Kadir\} and Fu-Sheng Wang and Han-Chieh Lin and Jee-Fu Huang and Jess Howell and Jidong Jia and Mohamed Alboraie and Roberts, \{Stuart K.\} and Masato Yoneda and Hasmik Ghazinian and Aram Mirijanyan and Yuemin Nan and Lesmana, \{Cosmas Rinaldi Adithya\} and Adams, \{Leon A.\} and Gamal Shiha and Manoj Kumar and Necati Oermeci and Lai Wei and George Lau and Masao Omata and Sarin, \{Shiv K.\} and Jacob George",

year = "2025",

month = apr,

doi = "10.1007/s12072-024-10774-3",

language = "English",

volume = "19",

pages = "261--301",

journal = "Hepatology International",

issn = "1936-0533",

publisher = "Springer",

number = "2",

}

Eslam, M, Fan, J-G, Yu, M-L, Wong, VW-S, Cua, IH, Liu, C-J, Tanwandee, T, Gani, R, Seto, W-K, Alam, S, Young, DY, Hamid, S, Zheng, M-H, Kawaguchi, T, Chan, W-K, Payawal, D, Tan, S-S, Goh, GB, Strasser, SI, Viet, HD, Kao, J-H, Kim, W, Kim, SU, Keating, SE, Yilmaz, Y, Kamani, L, Wang, C-C, Fouad, Y, Abbas, Z, Treeprasertsuk, S, Thanapirom, K, Al Mahtab, M, Lkhagvaa, U, Baatarkhuu, O, Choudhury, AK, Stedman, CAM, Chowdhury, A, Dokmeci, AK, Wang, F-S, Lin, H-C, Huang, J-F, Howell, J, Jia, J, Alboraie, M, Roberts, SK, Yoneda, M, Ghazinian, H, Mirijanyan, A, Nan, Y, Lesmana, CRA, Adams, LA, Shiha, G, Kumar, M, Oermeci, N, Wei, L, Lau, G, Omata, M, Sarin, SK & George, J 2025, 'The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease', Hepatology International, vol. 19, no. 2, e070189, pp. 261-301. https://doi.org/10.1007/s12072-024-10774-3

The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease. / Eslam, Mohammed; Fan, Jian-Gao; Yu, Ming-Lung et al.
In: Hepatology International, Vol. 19, No. 2, e070189, 04.2025, p. 261-301.

Research output: Contribution to journal › Article › peer-review

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T1 - The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease

AU - Eslam, Mohammed

AU - Fan, Jian-Gao

AU - Yu, Ming-Lung

AU - Wong, Vincent Wai-Sun

AU - Cua, Ian Homer

AU - Liu, Chun-Jen

AU - Tanwandee, Tawesak

AU - Gani, Rino

AU - Seto, Wai-Kay

AU - Alam, Shahinul

AU - Young, Dan Yock

AU - Hamid, Saeed

AU - Zheng, Ming-Hua

AU - Kawaguchi, Takumi

AU - Chan, Wah-Kheong

AU - Payawal, Diana

AU - Tan, Soek-Siam

AU - Goh, George Boon-bee

AU - Strasser, Simone I.

AU - Viet, Hang Dao

AU - Kao, Jia-Horng

AU - Kim, Won

AU - Kim, Seung Up

AU - Keating, Shelley E.

AU - Yilmaz, Yusuf

AU - Kamani, Lubna

AU - Wang, Chia-Chi

AU - Fouad, Yasser

AU - Abbas, Zaigham

AU - Treeprasertsuk, Sombat

AU - Thanapirom, Kessarin

AU - Al Mahtab, Mamun

AU - Lkhagvaa, Undram

AU - Baatarkhuu, Oidov

AU - Choudhury, Ashok Kumar

AU - Stedman, Catherine A. M.

AU - Chowdhury, Abhijit

AU - Dokmeci, A. Kadir

AU - Wang, Fu-Sheng

AU - Lin, Han-Chieh

AU - Huang, Jee-Fu

AU - Howell, Jess

AU - Jia, Jidong

AU - Alboraie, Mohamed

AU - Roberts, Stuart K.

AU - Yoneda, Masato

AU - Ghazinian, Hasmik

AU - Mirijanyan, Aram

AU - Nan, Yuemin

AU - Lesmana, Cosmas Rinaldi Adithya

AU - Adams, Leon A.

AU - Shiha, Gamal

AU - Kumar, Manoj

AU - Oermeci, Necati

AU - Wei, Lai

AU - Lau, George

AU - Omata, Masao

AU - Sarin, Shiv K.

AU - George, Jacob

PY - 2025/4

Y1 - 2025/4

N2 - Metabolic dysfunction-associated fatty liver disease (MAFLD) affects over one-fourth of the global adult population and is the leading cause of liver disease worldwide. To address this, the Asian Pacific Association for the Study of the Liver (APASL) has created clinical practice guidelines focused on MAFLD. The guidelines cover various aspects of the disease, such as its epidemiology, diagnosis, screening, assessment, and treatment. The guidelines aim to advance clinical practice, knowledge, and research on MAFLD, particularly in special groups. The guidelines are designed to advance clinical practice, to provide evidence-based recommendations to assist healthcare stakeholders in decision-making and to improve patient care and disease awareness. The guidelines take into account the burden of clinical management for the healthcare sector.

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KW - Chronic hepatitis-c

KW - Nonalcoholic steatohepatitis nash

KW - Hepatocellular-carcinoma patients

KW - B-virus infection

KW - Vitamin-e

KW - Bariatric surgery

KW - Risk-factors

KW - Portal-hypertension

KW - Multidisciplinary approach

KW - Calorie restriction

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SN - 1936-0533

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EP - 301

JO - Hepatology International

JF - Hepatology International

IS - 2

M1 - e070189

ER -

The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease

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