Abstract
Aim: The aim of the study was to measure the change in sub clinical inflammation (assessed by power doppler signal on ultrasound and high sensitivity C reactive protein (hsCRP) in patients with gout, over a12 weeks period, using a randomised, single blind study, comparing krill oil with colchicine
Methods: 21 patients were identified with a diagnosis of gout (according to the 2015 EULAR/ACR criteria) and evidence of inammation(as dened by a high sensitivity CRP > 5 or power doppler signal on ultra-sound in any of the examined joints). Patients were randomised to receive either 2 g of krill oil per day or 500mcg of colchicine, in addition to urate lowering therapy in accordance with 2012 ACR guidelines for the management of gout. Patients were observed over a 12 week period. At baseline, week 0, 6 and12, phlebotomy was performed (to measure hsCRP) and a joint ultrasound was undertaken (to assess for synovitis, tophi, erosions and aggregates).Patient questionnaire’s and physician assessments were also carried out at each time point. Result: Preliminary analysis suggests that there was only minimal change in the levels of subclinical inammation over the 12 week period in both arms of the study. There was no statistically signicant difference between the patients treated with krill oil, as compared to colchicine in achieving the primary outcomes. Conclusions: Preliminary results suggest neither krill oil nor colchicine were effective in reducing levels of subclinical inammation in patients with gout, as measured by hs CPR and ultrasound
Original language | English |
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Pages | 5-52 |
Number of pages | 48 |
DOIs | |
Publication status | Published - 1 Jul 2020 |
Event | Australian Rheumatology Association and Rheumatology Health Professionals Association 52nd Annual Scientific Meeting - Brisbane, Australia Duration: 14 May 2011 → 17 May 2011 |
Conference
Conference | Australian Rheumatology Association and Rheumatology Health Professionals Association 52nd Annual Scientific Meeting |
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Country/Territory | Australia |
City | Brisbane |
Period | 14/05/11 → 17/05/11 |