The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods

Laura M. Thornton, Melissa A. Munn-Chernoff, Jessica H. Baker, Anders Juréus, Richard Parker, Anjali K. Henders, Janne T. Larsen, Liselotte Petersen, Hunna J. Watson, Zeynep Yilmaz, Katherine M. Kirk, Scott Gordon, Virpi M. Leppä, Felicity C. Martin, David C. Whiteman, Catherine M. Olsen, Thomas M. Werge, Nancy L. Pedersen, Walter Kaye, Andrew W. Bergen & 26 others Katherine A. Halmi, Michael Strober, Allan S. Kaplan, D. Blake Woodside, James Mitchell, Craig L. Johnson, Harry Brandt, Steven Crawford, L. John Horwood, Joseph M. Boden, John F. Pearson, Laramie E. Duncan, Jakob Grove, Manuel Mattheisen, Jennifer Jordan, Martin A. Kennedy, Andreas Birgegård, Paul Lichtenstein, Claes Norring, Tracey D. Wade, Grant W. Montgomery, Nicholas G. Martin, Mikael Landén, Preben Bo Mortensen, Patrick F. Sullivan, Cynthia M. Bulik

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

Original languageEnglish
Pages (from-to)61-69
Number of pages9
JournalContemporary Clinical Trials
Volume74
DOIs
Publication statusPublished - 1 Nov 2018

Fingerprint

Anorexia Nervosa
Sweden
Denmark
New Zealand
Diagnostic and Statistical Manual of Mental Disorders
Social Media
Genetic Research
Amenorrhea
International Classification of Diseases
Feeding Behavior
Genomics
Internet
Psychiatry
Clinical Trials
Genome
Interviews

Cite this

Thornton, L. M., Munn-Chernoff, M. A., Baker, J. H., Juréus, A., Parker, R., Henders, A. K., ... Bulik, C. M. (2018). The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. Contemporary Clinical Trials, 74, 61-69. https://doi.org/10.1016/j.cct.2018.09.015
Thornton, Laura M. ; Munn-Chernoff, Melissa A. ; Baker, Jessica H. ; Juréus, Anders ; Parker, Richard ; Henders, Anjali K. ; Larsen, Janne T. ; Petersen, Liselotte ; Watson, Hunna J. ; Yilmaz, Zeynep ; Kirk, Katherine M. ; Gordon, Scott ; Leppä, Virpi M. ; Martin, Felicity C. ; Whiteman, David C. ; Olsen, Catherine M. ; Werge, Thomas M. ; Pedersen, Nancy L. ; Kaye, Walter ; Bergen, Andrew W. ; Halmi, Katherine A. ; Strober, Michael ; Kaplan, Allan S. ; Woodside, D. Blake ; Mitchell, James ; Johnson, Craig L. ; Brandt, Harry ; Crawford, Steven ; Horwood, L. John ; Boden, Joseph M. ; Pearson, John F. ; Duncan, Laramie E. ; Grove, Jakob ; Mattheisen, Manuel ; Jordan, Jennifer ; Kennedy, Martin A. ; Birgegård, Andreas ; Lichtenstein, Paul ; Norring, Claes ; Wade, Tracey D. ; Montgomery, Grant W. ; Martin, Nicholas G. ; Landén, Mikael ; Mortensen, Preben Bo ; Sullivan, Patrick F. ; Bulik, Cynthia M. / The Anorexia Nervosa Genetics Initiative (ANGI) : Overview and methods. In: Contemporary Clinical Trials. 2018 ; Vol. 74. pp. 61-69.
@article{e6bbf08122f042309a65f7c635846c9a,
title = "The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods",
abstract = "Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.",
keywords = "Anorexia nervosa, Eating disorders, Genome-wide association, Psychiatric genetics, Psychiatric genomics consortium, Social media",
author = "Thornton, {Laura M.} and Munn-Chernoff, {Melissa A.} and Baker, {Jessica H.} and Anders Jur{\'e}us and Richard Parker and Henders, {Anjali K.} and Larsen, {Janne T.} and Liselotte Petersen and Watson, {Hunna J.} and Zeynep Yilmaz and Kirk, {Katherine M.} and Scott Gordon and Lepp{\"a}, {Virpi M.} and Martin, {Felicity C.} and Whiteman, {David C.} and Olsen, {Catherine M.} and Werge, {Thomas M.} and Pedersen, {Nancy L.} and Walter Kaye and Bergen, {Andrew W.} and Halmi, {Katherine A.} and Michael Strober and Kaplan, {Allan S.} and Woodside, {D. Blake} and James Mitchell and Johnson, {Craig L.} and Harry Brandt and Steven Crawford and Horwood, {L. John} and Boden, {Joseph M.} and Pearson, {John F.} and Duncan, {Laramie E.} and Jakob Grove and Manuel Mattheisen and Jennifer Jordan and Kennedy, {Martin A.} and Andreas Birgeg{\aa}rd and Paul Lichtenstein and Claes Norring and Wade, {Tracey D.} and Montgomery, {Grant W.} and Martin, {Nicholas G.} and Mikael Land{\'e}n and Mortensen, {Preben Bo} and Sullivan, {Patrick F.} and Bulik, {Cynthia M.}",
year = "2018",
month = "11",
day = "1",
doi = "10.1016/j.cct.2018.09.015",
language = "English",
volume = "74",
pages = "61--69",
journal = "Controlled Clinical Trials",
issn = "0197-2456",
publisher = "Elsevier",

}

Thornton, LM, Munn-Chernoff, MA, Baker, JH, Juréus, A, Parker, R, Henders, AK, Larsen, JT, Petersen, L, Watson, HJ, Yilmaz, Z, Kirk, KM, Gordon, S, Leppä, VM, Martin, FC, Whiteman, DC, Olsen, CM, Werge, TM, Pedersen, NL, Kaye, W, Bergen, AW, Halmi, KA, Strober, M, Kaplan, AS, Woodside, DB, Mitchell, J, Johnson, CL, Brandt, H, Crawford, S, Horwood, LJ, Boden, JM, Pearson, JF, Duncan, LE, Grove, J, Mattheisen, M, Jordan, J, Kennedy, MA, Birgegård, A, Lichtenstein, P, Norring, C, Wade, TD, Montgomery, GW, Martin, NG, Landén, M, Mortensen, PB, Sullivan, PF & Bulik, CM 2018, 'The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods' Contemporary Clinical Trials, vol. 74, pp. 61-69. https://doi.org/10.1016/j.cct.2018.09.015

The Anorexia Nervosa Genetics Initiative (ANGI) : Overview and methods. / Thornton, Laura M.; Munn-Chernoff, Melissa A.; Baker, Jessica H.; Juréus, Anders; Parker, Richard; Henders, Anjali K.; Larsen, Janne T.; Petersen, Liselotte; Watson, Hunna J.; Yilmaz, Zeynep; Kirk, Katherine M.; Gordon, Scott; Leppä, Virpi M.; Martin, Felicity C.; Whiteman, David C.; Olsen, Catherine M.; Werge, Thomas M.; Pedersen, Nancy L.; Kaye, Walter; Bergen, Andrew W.; Halmi, Katherine A.; Strober, Michael; Kaplan, Allan S.; Woodside, D. Blake; Mitchell, James; Johnson, Craig L.; Brandt, Harry; Crawford, Steven; Horwood, L. John; Boden, Joseph M.; Pearson, John F.; Duncan, Laramie E.; Grove, Jakob; Mattheisen, Manuel; Jordan, Jennifer; Kennedy, Martin A.; Birgegård, Andreas; Lichtenstein, Paul; Norring, Claes; Wade, Tracey D.; Montgomery, Grant W.; Martin, Nicholas G.; Landén, Mikael; Mortensen, Preben Bo; Sullivan, Patrick F.; Bulik, Cynthia M.

In: Contemporary Clinical Trials, Vol. 74, 01.11.2018, p. 61-69.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The Anorexia Nervosa Genetics Initiative (ANGI)

T2 - Overview and methods

AU - Thornton, Laura M.

AU - Munn-Chernoff, Melissa A.

AU - Baker, Jessica H.

AU - Juréus, Anders

AU - Parker, Richard

AU - Henders, Anjali K.

AU - Larsen, Janne T.

AU - Petersen, Liselotte

AU - Watson, Hunna J.

AU - Yilmaz, Zeynep

AU - Kirk, Katherine M.

AU - Gordon, Scott

AU - Leppä, Virpi M.

AU - Martin, Felicity C.

AU - Whiteman, David C.

AU - Olsen, Catherine M.

AU - Werge, Thomas M.

AU - Pedersen, Nancy L.

AU - Kaye, Walter

AU - Bergen, Andrew W.

AU - Halmi, Katherine A.

AU - Strober, Michael

AU - Kaplan, Allan S.

AU - Woodside, D. Blake

AU - Mitchell, James

AU - Johnson, Craig L.

AU - Brandt, Harry

AU - Crawford, Steven

AU - Horwood, L. John

AU - Boden, Joseph M.

AU - Pearson, John F.

AU - Duncan, Laramie E.

AU - Grove, Jakob

AU - Mattheisen, Manuel

AU - Jordan, Jennifer

AU - Kennedy, Martin A.

AU - Birgegård, Andreas

AU - Lichtenstein, Paul

AU - Norring, Claes

AU - Wade, Tracey D.

AU - Montgomery, Grant W.

AU - Martin, Nicholas G.

AU - Landén, Mikael

AU - Mortensen, Preben Bo

AU - Sullivan, Patrick F.

AU - Bulik, Cynthia M.

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

AB - Background: Genetic factors contribute to anorexia nervosa (AN); and the first genome-wide significant locus has been identified. We describe methods and procedures for the Anorexia Nervosa Genetics Initiative (ANGI), an international collaboration designed to rapidly recruit 13,000 individuals with AN and ancestrally matched controls. We present sample characteristics and the utility of an online eating disorder diagnostic questionnaire suitable for large-scale genetic and population research. Methods: ANGI recruited from the United States (US), Australia/New Zealand (ANZ), Sweden (SE), and Denmark (DK). Recruitment was via national registers (SE, DK); treatment centers (US, ANZ, SE, DK); and social and traditional media (US, ANZ, SE). All cases had a lifetime AN diagnosis based on DSM-IV or ICD-10 criteria (excluding amenorrhea). Recruited controls had no lifetime history of disordered eating behaviors. To assess the positive and negative predictive validity of the online eating disorder questionnaire (ED100K-v1), 109 women also completed the Structured Clinical Interview for DSM-IV (SCID), Module H. Results: Blood samples and clinical information were collected from 13,363 individuals with lifetime AN and from controls. Online diagnostic phenotyping was effective and efficient; the validity of the questionnaire was acceptable. Conclusions: Our multi-pronged recruitment approach was highly effective for rapid recruitment and can be used as a model for efforts by other groups. High online presence of individuals with AN rendered the Internet/social media a remarkably effective recruitment tool in some countries. ANGI has substantially augmented Psychiatric Genomics Consortium AN sample collection. ANGI is a registered clinical trial: clinicaltrials.govNCT01916538; https://clinicaltrials.gov/ct2/show/NCT01916538?cond=Anorexia+Nervosa&draw=1&rank=3.

KW - Anorexia nervosa

KW - Eating disorders

KW - Genome-wide association

KW - Psychiatric genetics

KW - Psychiatric genomics consortium

KW - Social media

UR - http://www.scopus.com/inward/record.url?scp=85054436931&partnerID=8YFLogxK

U2 - 10.1016/j.cct.2018.09.015

DO - 10.1016/j.cct.2018.09.015

M3 - Article

VL - 74

SP - 61

EP - 69

JO - Controlled Clinical Trials

JF - Controlled Clinical Trials

SN - 0197-2456

ER -

Thornton LM, Munn-Chernoff MA, Baker JH, Juréus A, Parker R, Henders AK et al. The Anorexia Nervosa Genetics Initiative (ANGI): Overview and methods. Contemporary Clinical Trials. 2018 Nov 1;74:61-69. https://doi.org/10.1016/j.cct.2018.09.015