The allure of stem cell therapy for muscular dystrophy

Miranda Grounds, K.E. Davies

    Research output: Contribution to journalArticle

    24 Citations (Scopus)

    Abstract

    Duchenne muscular dystrophy (DMD) is a lethal muscle disease for which an effective treatment is urgently needed. The use of stem cells to produce normal muscle cells to replace the missing dystrophin protein has attracted much attention. Claims of success using stem cell treatment in animal models of human muscle diseases require careful evaluation and are not necessarily easily extrapolated to the clinical situation. Recent studies in the dystrophic dog model have been claimed to show that injected mesangioblasts, stem cells derived from blood vessels, reduce the severity of the disease. However, the authors' interpretation of the results did not consider that benefits might arise from the concomitant use of immunosuppressive drugs alone. (C) 2007 Elsevier B.V. All rights reserved.
    Original languageEnglish
    Pages (from-to)206-208
    JournalNeuromuscular Disorders
    Volume17
    Issue number3
    DOIs
    Publication statusPublished - 2007

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