Abstract
RECENT evidence suggests that a polymorphism in the regulatory region of the apolipoprotein E gene (APOE) is associated with an increased risk for developing Alzheimer's disease (AD) independent of that conveyed by the epsilon 4 allele of APOE. Previous work by our group indicated that plasma apolipoprotein E (apoE) levels were elevated in AD, raising the possibility that the genotype might modify AD risk by increasing expression of the APOE gene. In a total of 638 individuals the -491AA genotype was significantly associated with AD (P <0.005) while the TT genotype was associated with controls (P <0.005). In 138 individuals the AA genotype showed significantly higher plasma apoE levels, independent of epsilon 4 and AD status (P
Original language | English |
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Pages (from-to) | 879 - 882 |
Journal | NeuroReport |
Volume | 10 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1999 |