The -491AA polymorphism in the apoE gene is associated with Increased plasma APOE levels in Alzheimer's disease

S.M. Laws, Kevin Taddei, G. Martins, Athena Paton, C. Fisher, R. Clarnette, Joachim Hallmayer, W.S. Brooks, S.E. Gandy, Ralph Martins

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

RECENT evidence suggests that a polymorphism in the regulatory region of the apolipoprotein E gene (APOE) is associated with an increased risk for developing Alzheimer's disease (AD) independent of that conveyed by the epsilon 4 allele of APOE. Previous work by our group indicated that plasma apolipoprotein E (apoE) levels were elevated in AD, raising the possibility that the genotype might modify AD risk by increasing expression of the APOE gene. In a total of 638 individuals the -491AA genotype was significantly associated with AD (P <0.005) while the TT genotype was associated with controls (P <0.005). In 138 individuals the AA genotype showed significantly higher plasma apoE levels, independent of epsilon 4 and AD status (P
Original languageEnglish
Pages (from-to)879 - 882
JournalNeuroReport
Volume10
Issue number4
DOIs
Publication statusPublished - 1999

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