Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions

Jeremy Duczynski, Becky Fuller, Scott Stewart

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

© The Authors 2016.Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.
Original languageEnglish
Pages (from-to)1172-1179
JournalAustralian Journal of Chemistry
Volume69
Issue number10
DOIs
Publication statusPublished - 2016

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