Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions

Jeremy Duczynski; Becky Fuller; Scott Stewart

doi:10.1071/CH16097

Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions

Jeremy Duczynski, Becky Fuller, Scott Stewart

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

© The Authors 2016.Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.

Original language	English
Pages (from-to)	1172-1179
Number of pages	8
Journal	Australian Journal of Chemistry
Volume	69
Issue number	10
DOIs	https://doi.org/10.1071/CH16097
Publication status	Published - 2016

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title = "Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions",

abstract = "{\textcopyright} The Authors 2016.Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.",

author = "Jeremy Duczynski and Becky Fuller and Scott Stewart",

year = "2016",

doi = "10.1071/CH16097",

language = "English",

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T1 - Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions

AU - Duczynski, Jeremy

AU - Fuller, Becky

AU - Stewart, Scott

PY - 2016

Y1 - 2016

N2 - © The Authors 2016.Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.

AB - © The Authors 2016.Herein, we present the use of the tert-butyldimethylsilyl amine (TBDMS-NH2) as a silylating reagent for phenols, benzyl alcohols, and carboxylic acids. Unlike other silyl protection reactions, this reported process with TBDMS-NH2 does not involve the formation of HCl. Importantly, we report the efficacy of this reagent in operating under solvent-free conditions and enabling short reaction times.

U2 - 10.1071/CH16097

DO - 10.1071/CH16097

M3 - Article

SN - 0004-9425

VL - 69

SP - 1172

EP - 1179

JO - Australian Journal of Chemistry

JF - Australian Journal of Chemistry

IS - 10

ER -

Tert-Butyldimethylsilyl Amine (TBDMS-NH2): A Mild and Green Reagent for the Protection of Benzyl Alcohols, Phenols, and Carboxylic Acids under Solvent-Free Conditions

Abstract

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