Abstract
Terahertz Pulsed Imaging (TPI™) is a coherent imaging technique that can be used to reveal the dielectric properties of samples. Liver cirrhosis is a common disease that can lead to hepatocellular carcinoma. It has been previously studied in the microwave region and the dielectric parameters of human cirrhotic liver were quantified. In this study, we characterized the refractive index and absorption coefficient of cirrhotic and normal liver tissue from laboratory rats in the terahertz region using TPI. We observed that both the refractive index and absorption coefficient of the cirrhotic liver samples were consistently higher than those of the normal samples from 0.2 to 1.5 THz. After the samples were fixed in formalin solution for 24 hours, differences in the refractive index and absorption coefficient were still seen. These results illustrate the sensitivity of TPI to soft tissue and provide motivation for developing TPI into a clinical imaging technique.
| Original language | English |
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| Title of host publication | 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009 |
| DOIs | |
| Publication status | Published - 2009 |
| Event | 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009 - Busan, Korea, Republic of Duration: 21 Sep 2009 → 25 Sep 2009 |
Conference
| Conference | 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009 |
|---|---|
| Country | Korea, Republic of |
| City | Busan |
| Period | 21/09/09 → 25/09/09 |
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Terahertz Pulsed Imaging of liver cirrhosis. / Huang, Shengyang; Wang, Yi xiang; Yu, Jun; Ahuja, Anil T.; Wallace, Vincent P.; Zhang, Yuan Ting; Pickwell-Macpherson, Emma.
34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009. 2009. 5324758.Research output: Chapter in Book/Conference paper › Conference paper
TY - GEN
T1 - Terahertz Pulsed Imaging of liver cirrhosis
AU - Huang, Shengyang
AU - Wang, Yi xiang
AU - Yu, Jun
AU - Ahuja, Anil T.
AU - Wallace, Vincent P.
AU - Zhang, Yuan Ting
AU - Pickwell-Macpherson, Emma
PY - 2009
Y1 - 2009
N2 - Terahertz Pulsed Imaging (TPI™) is a coherent imaging technique that can be used to reveal the dielectric properties of samples. Liver cirrhosis is a common disease that can lead to hepatocellular carcinoma. It has been previously studied in the microwave region and the dielectric parameters of human cirrhotic liver were quantified. In this study, we characterized the refractive index and absorption coefficient of cirrhotic and normal liver tissue from laboratory rats in the terahertz region using TPI. We observed that both the refractive index and absorption coefficient of the cirrhotic liver samples were consistently higher than those of the normal samples from 0.2 to 1.5 THz. After the samples were fixed in formalin solution for 24 hours, differences in the refractive index and absorption coefficient were still seen. These results illustrate the sensitivity of TPI to soft tissue and provide motivation for developing TPI into a clinical imaging technique.
AB - Terahertz Pulsed Imaging (TPI™) is a coherent imaging technique that can be used to reveal the dielectric properties of samples. Liver cirrhosis is a common disease that can lead to hepatocellular carcinoma. It has been previously studied in the microwave region and the dielectric parameters of human cirrhotic liver were quantified. In this study, we characterized the refractive index and absorption coefficient of cirrhotic and normal liver tissue from laboratory rats in the terahertz region using TPI. We observed that both the refractive index and absorption coefficient of the cirrhotic liver samples were consistently higher than those of the normal samples from 0.2 to 1.5 THz. After the samples were fixed in formalin solution for 24 hours, differences in the refractive index and absorption coefficient were still seen. These results illustrate the sensitivity of TPI to soft tissue and provide motivation for developing TPI into a clinical imaging technique.
UR - http://www.scopus.com/inward/record.url?scp=72749087072&partnerID=8YFLogxK
U2 - 10.1109/ICIMW.2009.5324758
DO - 10.1109/ICIMW.2009.5324758
M3 - Conference paper
SN - 9781424454174
BT - 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009
ER -