Terahertz Pulsed Imaging of liver cirrhosis

Shengyang Huang, Yi xiang Wang, Jun Yu, Anil T. Ahuja, Vincent P. Wallace, Yuan Ting Zhang, Emma Pickwell-Macpherson

Research output: Chapter in Book/Conference paperConference paper

2 Citations (Scopus)

Abstract

Terahertz Pulsed Imaging (TPI™) is a coherent imaging technique that can be used to reveal the dielectric properties of samples. Liver cirrhosis is a common disease that can lead to hepatocellular carcinoma. It has been previously studied in the microwave region and the dielectric parameters of human cirrhotic liver were quantified. In this study, we characterized the refractive index and absorption coefficient of cirrhotic and normal liver tissue from laboratory rats in the terahertz region using TPI. We observed that both the refractive index and absorption coefficient of the cirrhotic liver samples were consistently higher than those of the normal samples from 0.2 to 1.5 THz. After the samples were fixed in formalin solution for 24 hours, differences in the refractive index and absorption coefficient were still seen. These results illustrate the sensitivity of TPI to soft tissue and provide motivation for developing TPI into a clinical imaging technique.

Original languageEnglish
Title of host publication34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009
DOIs
Publication statusPublished - 2009
Event34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009 - Busan, Korea, Republic of
Duration: 21 Sep 200925 Sep 2009

Conference

Conference34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009
CountryKorea, Republic of
CityBusan
Period21/09/0925/09/09

Fingerprint

Liver
Imaging techniques
Refractive index
Tissue
Medical imaging
Disease
Formaldehyde
Dielectric properties
Rats
Microwaves

Cite this

Huang, S., Wang, Y. X., Yu, J., Ahuja, A. T., Wallace, V. P., Zhang, Y. T., & Pickwell-Macpherson, E. (2009). Terahertz Pulsed Imaging of liver cirrhosis. In 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009 [5324758] https://doi.org/10.1109/ICIMW.2009.5324758
Huang, Shengyang ; Wang, Yi xiang ; Yu, Jun ; Ahuja, Anil T. ; Wallace, Vincent P. ; Zhang, Yuan Ting ; Pickwell-Macpherson, Emma. / Terahertz Pulsed Imaging of liver cirrhosis. 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009. 2009.
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title = "Terahertz Pulsed Imaging of liver cirrhosis",
abstract = "Terahertz Pulsed Imaging (TPI™) is a coherent imaging technique that can be used to reveal the dielectric properties of samples. Liver cirrhosis is a common disease that can lead to hepatocellular carcinoma. It has been previously studied in the microwave region and the dielectric parameters of human cirrhotic liver were quantified. In this study, we characterized the refractive index and absorption coefficient of cirrhotic and normal liver tissue from laboratory rats in the terahertz region using TPI. We observed that both the refractive index and absorption coefficient of the cirrhotic liver samples were consistently higher than those of the normal samples from 0.2 to 1.5 THz. After the samples were fixed in formalin solution for 24 hours, differences in the refractive index and absorption coefficient were still seen. These results illustrate the sensitivity of TPI to soft tissue and provide motivation for developing TPI into a clinical imaging technique.",
author = "Shengyang Huang and Wang, {Yi xiang} and Jun Yu and Ahuja, {Anil T.} and Wallace, {Vincent P.} and Zhang, {Yuan Ting} and Emma Pickwell-Macpherson",
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doi = "10.1109/ICIMW.2009.5324758",
language = "English",
isbn = "9781424454174",
booktitle = "34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009",

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Huang, S, Wang, YX, Yu, J, Ahuja, AT, Wallace, VP, Zhang, YT & Pickwell-Macpherson, E 2009, Terahertz Pulsed Imaging of liver cirrhosis. in 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009., 5324758, 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009, Busan, Korea, Republic of, 21/09/09. https://doi.org/10.1109/ICIMW.2009.5324758

Terahertz Pulsed Imaging of liver cirrhosis. / Huang, Shengyang; Wang, Yi xiang; Yu, Jun; Ahuja, Anil T.; Wallace, Vincent P.; Zhang, Yuan Ting; Pickwell-Macpherson, Emma.

34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009. 2009. 5324758.

Research output: Chapter in Book/Conference paperConference paper

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AU - Huang, Shengyang

AU - Wang, Yi xiang

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AU - Zhang, Yuan Ting

AU - Pickwell-Macpherson, Emma

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N2 - Terahertz Pulsed Imaging (TPI™) is a coherent imaging technique that can be used to reveal the dielectric properties of samples. Liver cirrhosis is a common disease that can lead to hepatocellular carcinoma. It has been previously studied in the microwave region and the dielectric parameters of human cirrhotic liver were quantified. In this study, we characterized the refractive index and absorption coefficient of cirrhotic and normal liver tissue from laboratory rats in the terahertz region using TPI. We observed that both the refractive index and absorption coefficient of the cirrhotic liver samples were consistently higher than those of the normal samples from 0.2 to 1.5 THz. After the samples were fixed in formalin solution for 24 hours, differences in the refractive index and absorption coefficient were still seen. These results illustrate the sensitivity of TPI to soft tissue and provide motivation for developing TPI into a clinical imaging technique.

AB - Terahertz Pulsed Imaging (TPI™) is a coherent imaging technique that can be used to reveal the dielectric properties of samples. Liver cirrhosis is a common disease that can lead to hepatocellular carcinoma. It has been previously studied in the microwave region and the dielectric parameters of human cirrhotic liver were quantified. In this study, we characterized the refractive index and absorption coefficient of cirrhotic and normal liver tissue from laboratory rats in the terahertz region using TPI. We observed that both the refractive index and absorption coefficient of the cirrhotic liver samples were consistently higher than those of the normal samples from 0.2 to 1.5 THz. After the samples were fixed in formalin solution for 24 hours, differences in the refractive index and absorption coefficient were still seen. These results illustrate the sensitivity of TPI to soft tissue and provide motivation for developing TPI into a clinical imaging technique.

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Huang S, Wang YX, Yu J, Ahuja AT, Wallace VP, Zhang YT et al. Terahertz Pulsed Imaging of liver cirrhosis. In 34th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2009. 2009. 5324758 https://doi.org/10.1109/ICIMW.2009.5324758