Terahertz pulse imaging in reflection geometry of human skin cancer and skin tissue

R.M. Woodward, B.E. Cole, Vincent Wallace, R.J. Pye, D.D. Arnone, E.H. Linfield, M. Pepper

    Research output: Contribution to journalArticle

    523 Citations (Scopus)

    Abstract

    We demonstrate the application of terahertz pulse imaging (TPI) in reflection geometry for the study of skin tissue and related cancers both III vitro and in vivo. The sensitivity of terahertz radiation to polar molecules, such as water. makes TPI suitable for studying the hydration levels in the skin and the determination of the lateral spread of skin cancer pre-operatively. By studying the terahertz pulse shape in the time domain we have been able to differentiate between diseased and normal tissue for the study of basal cell carcinoma (BCC). Basal cell carcinoma has shown a positive terahertz contrast, and inflammation and scar tissue a negative terahertz contrast compared to normal tissue. III vivo measurements on the stratum corneum have enabled visualization of the stratum corneum-epidermis interface and the study of skin hydration levels. These results demonstrate the potential of terahertz Pulse imaging for the study of skin tissue and its related disorders, both III vitro and III vivo.
    Original languageEnglish
    Pages (from-to)3853-3863
    JournalPhysics in Medicine and Biology
    Volume47
    Issue number21
    DOIs
    Publication statusPublished - 2002

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