Temporal and regional expression of Fos-related proteins in response to ischemic injury

Tanya L. Butler, Keith R. Pennypacker

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


The AP-1 transcription factor family has been widely studied in the response to ischemic brain injury. The data to date have demonstrated a complex involvement that depends on stimulus, subunit composition and brain region. One member in particular, the Fos-related antigen FRA-2, has demonstrated a potential for controlling neuroprotective gene expression. This study characterized the temporal and regional expression of a variety of proteins following ischemic injury induced by occlusion of the middle cerebral artery in rats. The results demonstrated upregulation of both c-Fos and FRA-2 in penumbral regions that preceded upregulation of the classic injury-associated proteins expressed by astrocytes and microglia and, in the case of FRA-2, appeared to correlate with neuronal survival. A further, previously undescribed, expression of FRA-2 in endothelial cells of the core ischemic region was also demonstrated.

Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalBrain Research Bulletin
Issue number1
Publication statusPublished - 1 Mar 2004
Externally publishedYes


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