Purpose: To evaluate the intraocular pressure (IOP) readings from two portable, telemedicine-friendly tonometers for suitability in glaucoma screening.Methods: 213 eyes of 107 consenting patients attending an eye clinic were tested with an I-care tonometer and a Pulsair-Easy Eye puff-air tonometer. Gold standard IOP was measured with a Goldmann applanation tonometer (GAT). Effect of central corneal thickness, anterior chamber depth and refractive errors on IOP measurements were also analysed.Results: The mean difference of IOP by GAT and both the portable tonometers was +/- 2.2 mmHg. The analysis indicates minimal difference between IOP readings of both the portable tonometers. The mean difference between two consecutive readings by I-care was 0.01 mmHg. Using 21 mmHg as a threshold for suspected glaucoma, both the portable digital tonometers reported a sensitivity of 38% and specificity of > 95%. In the subjects studied, central corneal thickness had statistically significant influence on IOP measurements while refractive errors and anterior chamber depth had no significant influence on IOP measurements with any tonometry.Conclusions: The IOP readings by both portable tonometers are comparable and were within clinically acceptable range from GAT. These portable tonometers are useful tools for IOP screening.