Technological Development and Advances for Constructing and Analyzing Plant Pangenomes

Haifei Hu, Risheng Li, Junliang Zhao, Jacqueline Batley, David Edwards

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)

Abstract

A pangenome captures the genomic diversity for a species, derived from a collection of genetic sequences of diverse populations. Advances in sequencing technologies have given rise to three primary methods for pangenome construction and analysis: de novo assembly and comparison, reference genome-based iterative assembly, and graph-based pangenome construction. Each method presents advantages and challenges in processing varying amounts and structures of DNA sequencing data. With the emergence of high-quality genome assemblies and advanced bioinformatic tools, the graph-based pangenome is emerging as an advanced reference for exploring the biological and functional implications of genetic variations.

Original languageEnglish
Article numberevae081
Number of pages9
JournalGenome Biology and Evolution
Volume16
Issue number4
DOIs
Publication statusPublished - Apr 2024

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