Gas hydrate formation when producing hydrocarbons has been managed with complete thermodynamic inhibition, avoiding solids formation during production. This is economically viable for conventional assets; however, increasing costs have led to a paradigm shift towards management rather than avoidance. This requires innovative operational techniques and chemical management strategies that are beyond our current modelling capability. This thesis offers a framework for building predictive hydrate management capabilities, allowing concrete assessments that are fundamentally rooted in economic metrics. This framework may inform the decision-making process for managing hydrates in flow assurance, by coupling mechanistic and probabilistic models to enable quantitative risk assessments.