Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response

C. Brand, M. A. Grimbaldeston, J. R. Gamble, J. Drew, J. J. Finlay-Jones, P. H. Hart

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: To examine the anti-inflammatory activities of tea tree oil (TTO) in vivo. Methods: Mice were sensitized to a chemical hapten, trinitrochlorobenzene, on their ventral skin and 7 days later challenged (or re-exposed) on their dorsal skin with the same hapten. Results: TTO applied 30 min before or up to 7 h after to the same dorsal site as hapten challenge caused a significant reduction in skin swelling after 24 h. TTO reduced oedema but not the influx of inflammatory cells. This finding was supported by the inability of TTO to suppress TNF α-induced E-selectin expression by human umbilical vein endothelial cells. TTO did not suppress irritant- or ultraviolet B-induced oedema. Conclusion: Topical TTO, specifically the TTO components, terpinen-4-ol and α-terpineol can regulate the oedema associated with the efferent phase of a contact hypersensitivity response.

Original languageEnglish
Pages (from-to)236-244
Number of pages9
JournalInflammation Research
Volume51
Issue number5
DOIs
Publication statusPublished - 1 Jan 2002
Externally publishedYes

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