Tea and flavonoid intake predict osteoporotic fracture risk in elderly Australian women: A prospective study

Gael Myers, Richard Prince, D.A. Kerr, A. Devine, R.J. Woodman, J.R. Lewis, Jonathan Hodgson

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    © 2015 American Society for Nutrition. Background: Observational studies have linked tea drinking, a major source of dietary flavonoids, with higher bone density. However, there is a paucity of prospective studies examining the association of tea drinking and flavonoid intake with fracture risk. Objective: The objective of this study was to examine the associations of black tea drinking and flavonoid intake with fracture risk in a prospective cohort of women aged .75 y. Design: A total of 1188 women were assessed for habitual dietary intake with a food-frequency and beverage questionnaire. Incidence of osteoporotic fracture requiring hospitalization was determined through the Western Australian Hospital Morbidity Data system. Multivariable adjusted Cox regression was used to examine the HRs for incident fracture. Results: Over 10 y of follow-up, osteoporotic fractures were identified in 288 (24.2%) women; 212 (17.8%) were identified as a major osteoporotic fracture, and of these, 129 (10.9%) were a hip fracture. In comparison with the lowest tea intake category (≥1 cup/wk), consumption of $3 cups/d was associated with a 30% decrease in the risk of any osteoporotic fracture (HR: 0.70; 95% CI: 0.50, 0.96). Compared with women in the lowest tertile of total flavonoid intake (from tea and diet), women in the highest tertile had a lower risk of any osteoporotic fracture (HR: 0.65; 95% CI: 0.47, 0.88), major osteoporotic fracture (HR: 0.66; 95% CI: 0.45, 0.95), and hip fracture (HR: 0.58; 95% CI: 0.36, 0.95). For specific classes of flavonoids, statistically significant reductions in fracture risk were observed for higher intake of flavonols for any osteoporotic fracture and major osteoporotic fracture, as well as flavones for hip fracture (P , 0.05). Conclusion: Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture-related hospitalizations in elderly women at high risk of fracture.
    Original languageEnglish
    Pages (from-to)958-965
    Number of pages8
    JournalAmerican Journal of Clinical Nutrition
    Volume102
    Issue number4
    Early online date12 Aug 2015
    DOIs
    Publication statusPublished - Oct 2015

    Fingerprint

    Osteoporotic Fractures
    Tea
    Flavonoids
    Prospective Studies
    Hip Fractures
    Drinking
    Hospitalization
    Flavones
    Food and Beverages
    Fracture Fixation
    Flavonols
    Information Systems
    Bone Density
    Observational Studies
    Diet
    Morbidity
    Incidence

    Cite this

    @article{4d21f4dd2c7d48228414cee19090bdd4,
    title = "Tea and flavonoid intake predict osteoporotic fracture risk in elderly Australian women: A prospective study",
    abstract = "{\circledC} 2015 American Society for Nutrition. Background: Observational studies have linked tea drinking, a major source of dietary flavonoids, with higher bone density. However, there is a paucity of prospective studies examining the association of tea drinking and flavonoid intake with fracture risk. Objective: The objective of this study was to examine the associations of black tea drinking and flavonoid intake with fracture risk in a prospective cohort of women aged .75 y. Design: A total of 1188 women were assessed for habitual dietary intake with a food-frequency and beverage questionnaire. Incidence of osteoporotic fracture requiring hospitalization was determined through the Western Australian Hospital Morbidity Data system. Multivariable adjusted Cox regression was used to examine the HRs for incident fracture. Results: Over 10 y of follow-up, osteoporotic fractures were identified in 288 (24.2{\%}) women; 212 (17.8{\%}) were identified as a major osteoporotic fracture, and of these, 129 (10.9{\%}) were a hip fracture. In comparison with the lowest tea intake category (≥1 cup/wk), consumption of $3 cups/d was associated with a 30{\%} decrease in the risk of any osteoporotic fracture (HR: 0.70; 95{\%} CI: 0.50, 0.96). Compared with women in the lowest tertile of total flavonoid intake (from tea and diet), women in the highest tertile had a lower risk of any osteoporotic fracture (HR: 0.65; 95{\%} CI: 0.47, 0.88), major osteoporotic fracture (HR: 0.66; 95{\%} CI: 0.45, 0.95), and hip fracture (HR: 0.58; 95{\%} CI: 0.36, 0.95). For specific classes of flavonoids, statistically significant reductions in fracture risk were observed for higher intake of flavonols for any osteoporotic fracture and major osteoporotic fracture, as well as flavones for hip fracture (P , 0.05). Conclusion: Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture-related hospitalizations in elderly women at high risk of fracture.",
    author = "Gael Myers and Richard Prince and D.A. Kerr and A. Devine and R.J. Woodman and J.R. Lewis and Jonathan Hodgson",
    year = "2015",
    month = "10",
    doi = "10.3945/ajcn.115.109892",
    language = "English",
    volume = "102",
    pages = "958--965",
    journal = "The American Journal of Clinical Nutrition",
    issn = "0002-9165",
    publisher = "American Society for Nutrition",
    number = "4",

    }

    Tea and flavonoid intake predict osteoporotic fracture risk in elderly Australian women: A prospective study. / Myers, Gael; Prince, Richard; Kerr, D.A.; Devine, A.; Woodman, R.J.; Lewis, J.R.; Hodgson, Jonathan.

    In: American Journal of Clinical Nutrition, Vol. 102, No. 4, 10.2015, p. 958-965.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Tea and flavonoid intake predict osteoporotic fracture risk in elderly Australian women: A prospective study

    AU - Myers, Gael

    AU - Prince, Richard

    AU - Kerr, D.A.

    AU - Devine, A.

    AU - Woodman, R.J.

    AU - Lewis, J.R.

    AU - Hodgson, Jonathan

    PY - 2015/10

    Y1 - 2015/10

    N2 - © 2015 American Society for Nutrition. Background: Observational studies have linked tea drinking, a major source of dietary flavonoids, with higher bone density. However, there is a paucity of prospective studies examining the association of tea drinking and flavonoid intake with fracture risk. Objective: The objective of this study was to examine the associations of black tea drinking and flavonoid intake with fracture risk in a prospective cohort of women aged .75 y. Design: A total of 1188 women were assessed for habitual dietary intake with a food-frequency and beverage questionnaire. Incidence of osteoporotic fracture requiring hospitalization was determined through the Western Australian Hospital Morbidity Data system. Multivariable adjusted Cox regression was used to examine the HRs for incident fracture. Results: Over 10 y of follow-up, osteoporotic fractures were identified in 288 (24.2%) women; 212 (17.8%) were identified as a major osteoporotic fracture, and of these, 129 (10.9%) were a hip fracture. In comparison with the lowest tea intake category (≥1 cup/wk), consumption of $3 cups/d was associated with a 30% decrease in the risk of any osteoporotic fracture (HR: 0.70; 95% CI: 0.50, 0.96). Compared with women in the lowest tertile of total flavonoid intake (from tea and diet), women in the highest tertile had a lower risk of any osteoporotic fracture (HR: 0.65; 95% CI: 0.47, 0.88), major osteoporotic fracture (HR: 0.66; 95% CI: 0.45, 0.95), and hip fracture (HR: 0.58; 95% CI: 0.36, 0.95). For specific classes of flavonoids, statistically significant reductions in fracture risk were observed for higher intake of flavonols for any osteoporotic fracture and major osteoporotic fracture, as well as flavones for hip fracture (P , 0.05). Conclusion: Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture-related hospitalizations in elderly women at high risk of fracture.

    AB - © 2015 American Society for Nutrition. Background: Observational studies have linked tea drinking, a major source of dietary flavonoids, with higher bone density. However, there is a paucity of prospective studies examining the association of tea drinking and flavonoid intake with fracture risk. Objective: The objective of this study was to examine the associations of black tea drinking and flavonoid intake with fracture risk in a prospective cohort of women aged .75 y. Design: A total of 1188 women were assessed for habitual dietary intake with a food-frequency and beverage questionnaire. Incidence of osteoporotic fracture requiring hospitalization was determined through the Western Australian Hospital Morbidity Data system. Multivariable adjusted Cox regression was used to examine the HRs for incident fracture. Results: Over 10 y of follow-up, osteoporotic fractures were identified in 288 (24.2%) women; 212 (17.8%) were identified as a major osteoporotic fracture, and of these, 129 (10.9%) were a hip fracture. In comparison with the lowest tea intake category (≥1 cup/wk), consumption of $3 cups/d was associated with a 30% decrease in the risk of any osteoporotic fracture (HR: 0.70; 95% CI: 0.50, 0.96). Compared with women in the lowest tertile of total flavonoid intake (from tea and diet), women in the highest tertile had a lower risk of any osteoporotic fracture (HR: 0.65; 95% CI: 0.47, 0.88), major osteoporotic fracture (HR: 0.66; 95% CI: 0.45, 0.95), and hip fracture (HR: 0.58; 95% CI: 0.36, 0.95). For specific classes of flavonoids, statistically significant reductions in fracture risk were observed for higher intake of flavonols for any osteoporotic fracture and major osteoporotic fracture, as well as flavones for hip fracture (P , 0.05). Conclusion: Higher intake of black tea and particular classes of flavonoids were associated with lower risk of fracture-related hospitalizations in elderly women at high risk of fracture.

    U2 - 10.3945/ajcn.115.109892

    DO - 10.3945/ajcn.115.109892

    M3 - Article

    VL - 102

    SP - 958

    EP - 965

    JO - The American Journal of Clinical Nutrition

    JF - The American Journal of Clinical Nutrition

    SN - 0002-9165

    IS - 4

    ER -