Targeting transcription factor STAT3 for cancer prevention and therapy

Edna Zhi Pei Chai; Muthu K. Shanmugam; Frank Arfuso; Arunasalam Dharmarajan; Chao Wang; Alan Prem Kumar; Ramar Perumal Samy; Lina H.K. Lim; Lingzhi Wang; Boon Cher Goh; Kwang Seok Ahn; Kam Man Hui; Gautam Sethi

doi:10.1016/j.pharmthera.2015.10.004

Targeting transcription factor STAT3 for cancer prevention and therapy

Edna Zhi Pei Chai
, Muthu K. Shanmugam
, Frank Arfuso
, Arunasalam Dharmarajan
, Chao Wang
, Alan Prem Kumar
, Ramar Perumal Samy
, Lina H.K. Lim
, Lingzhi Wang
, Boon Cher Goh
, Kwang Seok Ahn
, Kam Man Hui
, Gautam Sethi

School of Biomedical Sciences

Research output: Contribution to journal › Review article › peer-review

263 Citations (Scopus)

Abstract

Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.

Original language	English
Pages (from-to)	86-97
Number of pages	12
Journal	Pharmacology and Therapeutics
Volume	162
DOIs	https://doi.org/10.1016/j.pharmthera.2015.10.004
Publication status	Published - 1 Jun 2016

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10.1016/j.pharmthera.2015.10.004

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title = "Targeting transcription factor STAT3 for cancer prevention and therapy",

abstract = "Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.",

keywords = "Angiogenesis, Apoptosis, Cancer, Cytokines, Proliferation, STAT3",

author = "Chai, \{Edna Zhi Pei\} and Shanmugam, \{Muthu K.\} and Frank Arfuso and Arunasalam Dharmarajan and Chao Wang and Kumar, \{Alan Prem\} and Samy, \{Ramar Perumal\} and Lim, \{Lina H.K.\} and Lingzhi Wang and Goh, \{Boon Cher\} and Ahn, \{Kwang Seok\} and Hui, \{Kam Man\} and Gautam Sethi",

note = "Funding Information: This work was supported by NUHS Bench-to-Bedside grant to GS. APK is supported by grants from the National Medical Research Council of Singapore [ R-713-000-177-511 ], NUHS Bench-to-Bedside-To-Product [ R-184-000-243-515 ], the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore and by the NCIS Yong Siew Yoon Research Grant through donations from the Yong Loo Lin Trust. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2016",

month = jun,

day = "1",

doi = "10.1016/j.pharmthera.2015.10.004",

language = "English",

volume = "162",

pages = "86--97",

journal = "Pharmacology and Therapeutics",

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AU - Chai, Edna Zhi Pei

AU - Shanmugam, Muthu K.

AU - Arfuso, Frank

AU - Dharmarajan, Arunasalam

AU - Wang, Chao

AU - Kumar, Alan Prem

AU - Samy, Ramar Perumal

AU - Lim, Lina H.K.

AU - Wang, Lingzhi

AU - Goh, Boon Cher

AU - Ahn, Kwang Seok

AU - Hui, Kam Man

AU - Sethi, Gautam

N1 - Funding Information: This work was supported by NUHS Bench-to-Bedside grant to GS. APK is supported by grants from the National Medical Research Council of Singapore [ R-713-000-177-511 ], NUHS Bench-to-Bedside-To-Product [ R-184-000-243-515 ], the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore and by the NCIS Yong Siew Yoon Research Grant through donations from the Yong Loo Lin Trust. Publisher Copyright: © 2015 Elsevier Inc.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.

AB - Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.

KW - Angiogenesis

KW - Apoptosis

KW - Cancer

KW - Cytokines

KW - Proliferation

KW - STAT3

UR - https://www.scopus.com/pages/publications/84957612113

U2 - 10.1016/j.pharmthera.2015.10.004

DO - 10.1016/j.pharmthera.2015.10.004

M3 - Review article

C2 - 26478441

AN - SCOPUS:84957612113

SN - 0163-7258

VL - 162

SP - 86

EP - 97

JO - Pharmacology and Therapeutics

JF - Pharmacology and Therapeutics

ER -

Targeting transcription factor STAT3 for cancer prevention and therapy

Abstract

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