@article{72f6e9978b1a4d35b8ef2e3ec6bce3bb,
title = "Targeting transcription factor STAT3 for cancer prevention and therapy",
abstract = "Signal Transducers and Activators of Transcription (STATs) comprise an important class of transcription factors that have been implicated in a wide variety of essential cellular functions related to proliferation, survival, and angiogenesis. Among various STAT members, STAT3 is frequently overexpressed in tumor cells as well as tissue samples, and regulates the expression of numerous oncogenic genes controlling the growth and metastasis of tumor cells. The current review briefly discusses the importance of STAT3 as a potential target for cancer therapy and also provides novel insights into various classes of existing pharmacological inhibitors of this transcription factor that can be potentially developed as anti-cancer drugs.",
keywords = "Angiogenesis, Apoptosis, Cancer, Cytokines, Proliferation, STAT3",
author = "Chai, {Edna Zhi Pei} and Shanmugam, {Muthu K.} and Frank Arfuso and Arunasalam Dharmarajan and Chao Wang and Kumar, {Alan Prem} and Samy, {Ramar Perumal} and Lim, {Lina H.K.} and Lingzhi Wang and Goh, {Boon Cher} and Ahn, {Kwang Seok} and Hui, {Kam Man} and Gautam Sethi",
note = "Funding Information: This work was supported by NUHS Bench-to-Bedside grant to GS. APK is supported by grants from the National Medical Research Council of Singapore [ R-713-000-177-511 ], NUHS Bench-to-Bedside-To-Product [ R-184-000-243-515 ], the National Research Foundation Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative to Cancer Science Institute of Singapore, National University of Singapore and by the NCIS Yong Siew Yoon Research Grant through donations from the Yong Loo Lin Trust. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2016",
month = jun,
day = "1",
doi = "10.1016/j.pharmthera.2015.10.004",
language = "English",
volume = "162",
pages = "86--97",
journal = "Pharmacology and Therapeutics",
issn = "0163-7258",
publisher = "Elsevier",
}
