Targeting large molecules to mitochondria

A Muratovska, R N Lightowlers, R W Taylor, J A Wilce, M P Murphy

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

Mitochondrial function is central to a range of cell processes and mitochondrial dysfunction contributes to a number of human diseases. Consequently there is growing interest in delivering large molecules such as nucleic acids, proteins, enzyme mimetics, drugs and probes to mitochondria within cells. The reasons for doing this are to understand how mitochondria function in the cell and to develop therapies for diseases involving mitochondrial damage. Here we review the methods that have been used to target large molecules to mitochondria and discuss some approaches under development.

Original languageEnglish
Pages (from-to)189-198
Number of pages10
JournalAdvanced Drug Delivery Reviews
Volume49
Issue number1-2
Publication statusPublished - 2 Jul 2001

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    Muratovska, A., Lightowlers, R. N., Taylor, R. W., Wilce, J. A., & Murphy, M. P. (2001). Targeting large molecules to mitochondria. Advanced Drug Delivery Reviews, 49(1-2), 189-198.